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2012 Fiscal Year Final Research Report

Development of minimally invasive treatment for severe tracheomalacia using drug delivery system and growth factors

Research Project

  • PDF
Project/Area Number 22591977
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionThe University of Tokyo

Principal Investigator

SUGIYAMA Masahiko  東京大学, 医学部附属病院, 講師 (00270877)

Co-Investigator(Kenkyū-buntansha) KOMURA Makoto  埼玉医科大学, 医学部, 教授 (10422289)
TABATA Yasuhiko  京都大学, 再生医科学研究所, 教授 (50211371)
Project Period (FY) 2010 – 2012
Keywords気管軟化症 / 成長因子 / ドラッグデリバリーシステム
Research Abstract

This study showed that slowly released b-FGF enlarges the tracheal lumen and thickens the cartilage dose-dependently. Symptoms of tracheomalacia usually improve with age. Rapid growth of tracheal cartilage inducedby slowly released b-FGF could possibly act as a novel treatment for tracheaomalacia.

  • Research Products

    (3 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Slow release of basic fibroblast growth factor (b-FGF) promotes growth of tracheal cartilage.2013

    • Author(s)
      Ishimaru T, Komura M, Sugiyama M, Tabata Y.
    • Journal Title

      J Pediatr Surg

      Volume: 48(2) Pages: 288-92

    • Peer Reviewed
  • [Presentation] b-FGF徐放による気管の成長促進 重症気管軟化症に対する新治療法開発2013

    • Author(s)
      石丸哲也,古村眞,杉山正彦,田畑泰彦
    • Organizer
      横浜
    • Year and Date
      2013-03-23
  • [Presentation] Slow Release of Basic Fibroblast Growth Factor (b-FGF) Promotes Growth of Tracheal Cartilage2012

    • Author(s)
      Ishimaru T, Komura M, Masahiko Sugiyama M, Tabata Y
    • Organizer
      EUPSA/BAPS joint meeting 2012
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2012-06-14

URL: 

Published: 2014-08-29  

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