2012 Fiscal Year Final Research Report
Molecular biological resolution of hindgut embryogenesis with a rescue program for anorectal malformations induced by retinoic acid in mice
| Project/Area Number |
22591982
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SASAKI Yasunari 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (30405253)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Shigeru 自治医科大学, 医学部, 准教授 (00315962)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 先天性消化器疾患学 / 直腸肛門奇形 / 遺伝的組織系譜解析 |
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| Research Abstract |
In the embryos administered ATRA only, over 95% demonstrated ARM. In the embryos administered both ATRA and LE135, however, 44% of the embryos demonstrated normal development of the rectum and anus. Therefore, these findings indicate that RA receptor antagonist prevents disturbance of the cell signaling pathway between the epithelium and the mesenchyme layers because RA receptor antagonist inhibits RA receptor from forming heterodimers with retinoid X receptors.
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