2012 Fiscal Year Final Research Report
A new approach for immunotherapy in neuroblastoma using immunogenic dead cell induced by doxorubicin
| Project/Area Number |
22591984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児腫瘍学 |
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| Research Abstract |
Doxorubicin can induce immunogenic apoptotic cell death in the neuroblastoma cells, and thus has an immunological advantage in chemotherapy of neuroblastoma. BM -DC is considered to be the key antigen presenting cell in the immune reaction after immunogenic apoptotic neuroblastoma cell phagocytosis. These mechanisms could be able to apply for developing new vaccine therapy for advanced neuroblastoma.
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