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2012 Fiscal Year Final Research Report

Molecular mechanism of transmembrane proteins :Construction of therapeutic strategy for lymph edema

Research Project

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Project/Area Number 22591998
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Plastic surgery
Research InstitutionEhime University

Principal Investigator

NAKAOKA Hiroki  愛媛大学, 医学部附属病院, 准教授 (30172266)

Co-Investigator(Kenkyū-buntansha) HIRAKAWA Satoshi  浜松医科大学, 医学部, 准教授 (50419511)
Project Period (FY) 2010 – 2012
Keywords創傷治癒学 / リンパ管新生
Research Abstract

The present study demonstrated that endogenous or ectopic growth factors induce the ectodomain shedding of type I transmembrane proteins in cultured human dermal lymphatic endothelial cells. The ectodomain shedding enhanced the endothelial cell migration. Thus, these results indicate that the membrane-anchored proteins can promote lymphangiogenesis, and provide a novel therapeutic strategy for lymph edema.

  • Research Products

    (14 results)

All 2013 2012 2011 2010

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 顔面腫瘍(瘤)の分類 ‐受診世代による分類とその特徴-2013

    • Author(s)
      中岡啓喜
    • Journal Title

      形成外科

      Volume: 56巻 Pages: 365-376

    • Peer Reviewed
  • [Journal Article] 基底細胞癌に関するクリニカル・クエッションを作成して2012

    • Author(s)
      中岡啓喜
    • Journal Title

      形成外科

      Volume: 55巻 Pages: 737-746

    • Peer Reviewed
  • [Journal Article] A palmtop-sized microfluidic cell culture system driven by a miniaturized infusion pump2012

    • Author(s)
      Sasaki N, Shinjo M, Hirakawa S, Nishinaka M, Tanaka Y, Mawatari K,Kitamori T, Sato K
    • Journal Title

      Electrophoresis

      Volume: 33 Pages: 1729-1735

  • [Journal Article] Targeted overexpression of Angptl6/angiopoietin -related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet2012

    • Author(s)
      Okazaki H, Hirakawa S, Shudou M, Nakaoka Y, Shirakata Y, Miyata K, Oike Y, Hashimoto K, Sayama K
    • Journal Title

      B J Dermatol

      Volume: 39 Pages: 366-74

  • [Journal Article] 手術治療を要した毛細血管奇形症例の検討2011

    • Author(s)
      山下昌宏、中岡啓喜、森秀樹、松本健吾、見崎麻由
    • Journal Title

      日本形成外科学会会誌

      Volume: 31巻 Pages: 7-13

    • Peer Reviewed
  • [Journal Article] Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis2011

    • Author(s)
      Aoi J, Endo M, Kadomatsu T, Miyata K, Nakano M, Horiguchi H, Ogata A, Odagiri H, Yano M, Araki K, Jinnin M, Ito T, Hirakawa S, Ihn H, Oike Y
    • Journal Title

      Cancer Res.

      Volume: 71 Pages: 7502-12

  • [Journal Article] Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.2011

    • Author(s)
      Kerjaschki D, Bago-Horvath Z, Rudas M, Sexl V, Schneckenleithner C, Wolbank S, Bartel G, Krieger S, Kalt R, Hantusch B, Keller T, Nagy-Bojarszky K, Huttary N, Raab I, Lackner K, Krautgasser K, Schachner H, Kaserer K, Rezar S, Madlener S, Vonach C, Davidovits A, Nosaka H, Hammerle M, Viola K, Dolznig H, Schreiber M, Nader A, Mikulits W, Gnant M, Hirakawa S, Detmar M, Alitalo K, Nijman S, Offner F, Maier TJ, Steinhilber D, Krupitza G
    • Journal Title

      J Clin Invest.

      Volume: 121 Pages: 2000-12

  • [Journal Article] 母斑症2010

    • Author(s)
      中岡啓喜
    • Journal Title

      形成外科

      Volume: 53巻 Pages: 765-774

    • Peer Reviewed
  • [Journal Article] 口唇の体表悪性腫瘍における治療戦略2010

    • Author(s)
      中岡啓喜
    • Journal Title

      PEPARS

      Volume: 46巻 Pages: 41-49

    • Peer Reviewed
  • [Journal Article] リンパ管の発生・再生 基礎から臨床へ 皮膚疾患とリンパ管新生病態解明を目指して2010

    • Author(s)
      平川聡史
    • Journal Title

      リンパ学

      Volume: 33巻 Pages: 48-49

    • Peer Reviewed
  • [Journal Article] PPARγ mediates innate immunity by regulating the 1α,25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes2010

    • Author(s)
      Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, Hashimoto K
    • Journal Title

      J Dermatol Sci

      Volume: 60 Pages: 179-86

  • [Journal Article] E2 polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity2010

    • Author(s)
      Sayama K, Yamamoto M, Shirakata Y, Hanakawa Y, Hirakawa S, Dai X, Tohyama M, Tokumaru S, Shin MS, Sakurai H, Akira S, Hashimoto K
    • Journal Title

      J Biol Chem

      Volume: 39 Pages: 30042-9

  • [Presentation] 皮膚と循環:血管・リンパ管から考える病態生理. シンポジウム:階層的循環システム構築の機序とその破綻(指定演題)2013

    • Author(s)
      平川聡史
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
  • [Patent(Industrial Property Rights)] 血管透過性亢進抑制作用の評価法法2013

    • Inventor(s)
      山内 豊彦、平川聡史、山下 豊、戸倉新樹
    • Industrial Property Rights Holder
      国立大学法人浜松医科大学・浜松ホトニクス株式会社
    • Industrial Property Number
      特願 2013-034570
    • Filing Date
      2013-02-25

URL: 

Published: 2014-08-29  

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