2012 Fiscal Year Final Research Report
High quality cardiopulmonary-brain resuscitation with antioxidant administration just before starting resuscitation (Animal study)
| Project/Area Number |
22592007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOMURA Ryosuke 東北大学, 大学病院, 助教 (90400358)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 心肺停止 / 酸化 / 抗酸化 / 虚血再灌流 / 酸化ストレス度 / 抗酸化力 / 蘇生 |
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| Research Abstract |
We devised brain ischemia and reperfusion animal (rat) model analogous to blood oxidative and anti-oxidative states observed in Vegetative State patients after cardiac and pulmonary arrest and resuscitation. In this model, Vitamin C 10mg and 20mg/body administrations just before reperfusion suppressed the increase of plasma reactive oxygen metabolites after the reperfusion and Vitamin C 20mg/body administration just before reperfusion increased the plasma biological antioxidant potential.
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