2012 Fiscal Year Final Research Report
Intracerebral monitoring of oxidative stress for acute brain injury using microdialysis
| Project/Area Number |
22592016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKITA Kenya 香川大学, 医学部附属病院, 講師 (10505803)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 心停止後症候群 / 重症頭部外傷 / マイクロダイアリシス / glycerol / glutamate / glucose / lactate/pyruvate 比 / Targeted temperature management / 神経集中治療 |
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| Research Abstract |
This study evaluates the neurochemical changes in patients with traumatic brain injury (TBI) or post cardiac arrest syndrome (PCAS) using brain microdialysis. In TBI, large fluctuation of lactate/pyruvate ratio indicating poor outcome may related to cortical spreading depression. Lower cerebral perfusion pressure (CPP) under 60 mmHg relates increase of MD glycerol and decrease of MD glucose in TBI. In CPA patients, MD glycerol rose immediately and transiently after every intravenous glycerol (osmotic diuretic) administration, especially in poor outcome case. Lower CPP under 60 mmHg relates increase of MD glutamate in CPA. Plasma lactate and glucose relates MD lactate and MD glucose, respectively in CPA. Intracerebral MD parameter values must be analyzed with systemic parameters and the location of MD probe (the severity of the brain damage).
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Research Products
(11 results)
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[Journal Article] Neurological Benefit of Therapeutic Hypothermia Following Return of Spontaneous Circulation for Out-of-Hospital Non-Shockable Cardiac Arrest.2012
Author(s)
Taketomo Soga, Ken Nagao, Hirotaka Sawano, Hiroyuki Yokoyama, Yoshio Tahara, Mamoru Hase, Takayuki Otani, Shinichi Shirai, Hiroshi Hazui, Hideki Arimoto, Kazunori Kashiwase, Shunji Kasaoka, Tomokazu Motomura, Yasuhiro Kuroda, Yuji Yasuga, Naohiro Yonemoto, Hiroshi Nonogi, for the J-PULSE-Hypo Investigators
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Journal Title
Circ J
Volume: 76
Pages: 2579 - 2585
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[Journal Article] Impact of Therapeutic Hypothermia in the Treatment of Patients With Out-of-Hospital Cardiac Arrest From the J-PULSE-HYPO Study Registry.2011
Author(s)
Hiroyuki Yokoyama, Ken Nagao, Mamoru Hase, Yoshio Tahara, Hiroshi Hazui, Hideki Arimoto, Kazunori Kashiwase, Hirotaka Sawano, Yuji Yasuga, Yasuhiro Kuroda, Shunji Kasaoka, Shinichi Shirai, Naohiro Yonemoto, Hiroshi Nonogi, for the J-PULSE-Hypo Investigators.
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Journal Title
Circ J
Volume: 75
Pages: 1063 - 1070
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