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2012 Fiscal Year Final Research Report

Assessment of brain damage after carbon monoxide poisoning using diffusion tensor imaging

Research Project

  • PDF
Project/Area Number 22592020
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionIwate Medical University

Principal Investigator

BEPPU Takaaki  岩手医科大学, 医学部, 准教授 (70275543)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Shunrou  岩手医科大学, 医学部, 助教 (60405842)
Project Period (FY) 2010 – 2012
KeywordsCO中毒 / 大脳白質障害 / 拡散テンソル画像 / MRS
Research Abstract

The aim of this study is whether neuroimaging techniques such as diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS) are able to show quantitatively brain damage after carbon monoxide poisoning. We clarified that DTI and MRS demonstrate objectively and quantitatively pathological changes of the cerebral white matter after carbon monoxide poisoning, and also predict afterward prognoses in patients.

  • Research Products

    (11 results)

All 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (3 results)

  • [Journal Article] Two patients with delayed neuropsychiatric sequelae caused by exposure to carbon monoxide under the same conditions.2012

    • Author(s)
      Kudo K, Sanjo K, Koizumi N, Koeda A, Otsuka K, Beppu T, Endo S, Sakai A.
    • Journal Title

      Prim Care Companion CNS Disord.

      Volume: 14(3)

    • DOI

      DOI:10.4088/PCC.11l01316.

    • Peer Reviewed
  • [Journal Article] Fractional anisotropy in the centrum semiovale as a quantitative indicator of cerebral white matter damage in the subacute phase in patients with carbon monoxide poisoning: correlation with concentration of myelin basic protein in cerebrospinal fluid.2012

    • Author(s)
      Beppu T, Fujiwara S, Nishimoto H, KoedaA, NarumiS, Mori K, Ogasawara K, SasakiM:
    • Journal Title

      J Neurol

      Volume: 259(8) Pages: 1698 -705

    • DOI

      DOI:10.1007/s00415-011-6402-5.

    • Peer Reviewed
  • [Journal Article] Detecting damaged regions of cerebral white matter in the subacute phase after carbon monoxide poisoning using voxel-based analysis with diffusion tensor imaging.2012

    • Author(s)
      Fujiwara S, Beppu T, Nishimoto H, Sanjo K, Koeda A, Mori K, Kudo K, Sasaki S, OgasawaraK:
    • Journal Title

      Neuroradiology

      Volume: 54 Pages: 681 -689

    • DOI

      DOI:10.1007/s00234-011-0958-8.

    • Peer Reviewed
  • [Journal Article] 1H-magnetic resonance spectroscopy indicates damage to cerebral white matter in the subacute phase after CO poisoning.2011

    • Author(s)
      Beppu T, Nishimoto H, Fujiwara S , Kudo K, Sanjo K, Narumi S, Oikawa H, Onodera M, Ogasawara K, Sasaki M
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 82(8) Pages: 869-75

    • DOI

      DOI:10.1136/jnnp.2010.222422

    • Peer Reviewed
  • [Journal Article] 拡散テンソル画像を用いたCO中毒後大脳白質障害の評価日本高気圧環境・2011

    • Author(s)
      別府高明、西本英明、藤原俊朗、小笠原邦昭、鎌田 桂
    • Journal Title

      潜水医学会雑誌

      Volume: 45 Pages: 208

    • Peer Reviewed
  • [Journal Article] Assessment of damage to cerebral white matter fiber in the subacute phase after carbon monoxide poisoning using fractional anisotropy in diffusion tensor imaging2010

    • Author(s)
      Beppu T, NishimotoH, IshigakiD, FujiwaraS, YoshidaY, OikawaH, KamadaK, SasakiM, OgasawaraK:
    • Journal Title

      Neuroradiology

      Volume: 52 (8) Pages: 735-743

    • DOI

      DOI:10.1007/s00234-009-0649-x

    • Peer Reviewed
  • [Journal Article] 急性一酸化炭素(CO)中毒におけるCOガスの暴露時間と頭部CT/MRI異常所見の関連性2010

    • Author(s)
      小野寺 誠、藤野靖久、井上義博、菊池哲、及川博隆、別府高明、遠藤重厚
    • Journal Title

      日本救急医学会雑誌

      Volume: 21 Pages: 951-955

    • Peer Reviewed
  • [Journal Article] The role of MR imaging in assessing brain damage from carbon monoxide poisoning: a review of the literature.

    • Author(s)
      Beppu T
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] CO中毒に対するエダラボンによる抗酸化作用の臨床的評価2012

    • Author(s)
      別府高明
    • Organizer
      第47回日本高気圧環境・潜水医学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-11-16
  • [Presentation] 拡散テンソル画像を用いたCO中毒後大脳白質障害の評価2010

    • Author(s)
      別府高明、他
    • Organizer
      第45回日本高気圧環境・潜水医学会学術総会岡山
    • Place of Presentation
      岡山
    • Year and Date
      2010-11-26
  • [Presentation] 一酸化炭素中毒による大脳白質障害の神経画像解析 -治療戦略とHBO2有用性の実証のために-2010

    • Author(s)
      別府高明
    • Organizer
      第2回日本高気圧環境・潜水医学会中国地方会
    • Place of Presentation
      山口
    • Year and Date
      2010-03-06

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Published: 2014-08-29  

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