2012 Fiscal Year Final Research Report
The study of the improvement mechanism with the pulmonary protective therapy of the acute pulmonary injury: Work of breathing analysis and microcirculation for an index
| Project/Area Number |
22592022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOMORI Makiko 東京女子医科大学, 医学部, 教授 (60178332)
TOMIZAWA Yasuko 東京女子医科大学, 医学部, 助教 (00159047)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 集中治療医学 |
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| Research Abstract |
In the fundamental research, microcirculation dynamics at sepsis was studied using the rabbit ear chamber (REC). An arteriolar vascular diameter, a blood flow rate and motions of venular leukocyte were directly recorded in REC and analyzed at the early stage of the sepsis. In the clinical research, arterial blood gas, chest X-ray, CT, a physical examination, and clinical course were analyzed by changing parameters of the ventilation modes for respirator wearing patients. We evaluated the work of breathing and the synchronous characteristics to spontaneous respiration, andfound a more physiological ventilation mode with higher therapeutic gain than conventional modes.
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