2012 Fiscal Year Final Research Report
The role of gut derived arachidonic acid in post-hemorrhagic shock mesenteric lymph on the development of distant organ injury
| Project/Area Number |
22592025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Norio 京都大学, 医学部, 講師 (30409205)
KUSHIMOTO Shigeki 東北大学, 医学研究科, 教授 (50195434)
YOKOTA Hiroyuki 日本医科大学, 医学研究科, 教授 (60182698)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腸管リンパ液 / 脂質メディエータ / 腸管虚血 / アラキドン酸 / 臓器障害 |
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| Research Abstract |
The purpose of this study is to determine the role of arachidonic acid in post-hemorrhagic shock mesenteric lymph (PSML) on the development of distant organ injury. We have shown that mesenteric ischemia generates phospholipase A2 protein in PSML, which induce neutrophil priming and acute lung injury in a two-event model. We have been investigating further mechanism of post-hemorrhagic shock mesenteric lymph inducedorgan injury including arachidonic acid.
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