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2012 Fiscal Year Final Research Report

The role of extracellular matrix degradation enzymes, MMP and ADAM in tumor micro environment (stem cell niche)

Research Project

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Project/Area Number 22592030
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionNational Center for Geriatrics and Gerontology (2011-2012)
Tokyo Medical and Dental University (2010)

Principal Investigator

NAKAMURA Hiroyuki  独立行政法人国立長寿医療研究センター, 再生歯科医療研究部, 副部長 (30542253)

Project Period (FY) 2010 – 2012
KeywordsADAM / MMP / TIMP3 / 癌幹細胞
Research Abstract

In oral tumor micro environment (stem cell niche), the role of extracellular matrix degradation enzymes, MMP and ADAM which is critical for tumor invasion and metastasis, is not clear. To address this question, we establish transgenic mice which overexpress MMP or ADAM specific inhibitor in niche cells specifically, and try to identify which protease is involved in regulation of oral tumor micro environment

  • Research Products

    (10 results)

All 2013 2012 2011 2010

All Journal Article (3 results) Presentation (6 results) Book (1 results)

  • [Journal Article] The anti-inflammatory effects of matrix metalloproteinase-3 on irreversible pulpitis of mature erupted teeth.2012

    • Author(s)
      Eba, H., Murasawa, Y., Iohara, K., Isogai, Z., Nakamura, H., Nakamura, H. and Nakashima, M.
    • Journal Title

      PloS one

      Volume: 7 Pages: e52523

  • [Journal Article] Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type I transcription.2011

    • Author(s)
      Bou-Gharios, G., Amin, F., Hill, P., Nakamura, H., Maxwell, P., and Fisk, NM.
    • Journal Title

      Cells Tissues Organs

      Volume: 193 Pages: 379-392

  • [Journal Article] Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.2010

    • Author(s)
      Sonnylal, S., Shi-Wen, X., Leoni, P., Naff, K., Van Pelt, CS., Nakamura, H., Leask, A., Abraham, D., Bou-Gharios, G., and de Crombrugghe, B.
    • Journal Title

      Arthritis Rheum

      Volume: 62 Pages: 1523-1532

  • [Presentation] 歯の再生医療2013

    • Author(s)
      中村博幸
    • Organizer
      平成25年度九州歯科大同窓会北陸支部学術講演会
    • Place of Presentation
      福井
    • Year and Date
      2013-03-02
  • [Presentation] 歯の再生医療2012

    • Author(s)
      中村博幸
    • Organizer
      平成24年度九州歯科大東京都同窓会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-13
  • [Presentation] MMP-3の歯髄炎での抗炎症, 組織再生作用の検討2012

    • Author(s)
      中村博幸
    • Organizer
      第10回日本再生歯科医学会(シンポジウムI)
    • Place of Presentation
      神戸
    • Year and Date
      2012-09-01
  • [Presentation] 歯科再生医療の背景と最先端事情2012

    • Author(s)
      中村博幸
    • Organizer
      第22回金沢歯科口腔外科懇話会
    • Place of Presentation
      金沢
    • Year and Date
      2012-02-25
  • [Presentation] 細胞外マトリックス分解最近の知見2011

    • Author(s)
      中村博幸
    • Organizer
      平成23年愛知医科大学分子医科学研究所フォーラム
    • Place of Presentation
      愛知
    • Year and Date
      2011-04-20
  • [Presentation] 細胞外マトリックス分解最近の知見2010

    • Author(s)
      中村博幸
    • Organizer
      第17回プロテオグリカンフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2010-02-27
  • [Book] 炎症メディエーターメタロプロテアーゼ2010

    • Author(s)
      中村博幸, 岡田保典
    • Total Pages
      195-199
    • Publisher
      日本臨床

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Published: 2014-08-29   Modified: 2014-09-16  

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