2012 Fiscal Year Final Research Report
A role of Wnt/beta-catenin signal network on the stimulated bone formation under mechanical stress.
| Project/Area Number |
22592036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
IKEGAME Mika 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70282986)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Keiichiro 金沢大学, 保健学系, 准教授 (80283117)
TABUCHI Yoshiaki 富山大学, 生命科学先端研究センター, 准教授 (20322109)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 骨形成・機械的刺激 / 局所因子 / サイトカイン / 骨縫合部組織 / Wnt |
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| Research Abstract |
We can stimulate bone formation with tensile stress on a suture of mouse calvaria. Gene expressions of many factors, especially Wnt/beta-catenin family which are involved in bone-cell activity were examined during the stimulated bone formation. We could show the relative expression ratios of some factors at each time point of the experiment. Those results suggested which factors were more important at each stage of the stimulated bone formation.
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