2012 Fiscal Year Final Research Report
The identification of cell surface antigen of oral streptococcus for development of vaccine for oral cancer
| Project/Area Number |
22592046
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
SASAKI Minoru 岩手医科大学, 歯学部, 准教授 (40187133)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Shigenobu 岩手医科大学, 歯学部, 教授 (10177917)
SHIMOYAMA Yu 岩手医科大学, 歯学部, 助教 (90453331)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | Streptococcus anginosus / フィブロネクチン結合タンパク質 / 上皮細胞 / 付着因子 |
|---|
| Research Abstract |
Streptococcus anginosus inhabits dental plaques, and its infection in oral mucosa could be closely related with some squamous cell carcinoma. In this study for the development of vaccine, the fibronectin binding protein gene of S. anginosus, designated fbp62 was cloned, and the pathogenic involvement of Fbp62 in S. anginosusinfection was investigated. The results indicated that the adhesive ability of an fbp62knockout mutan t (Dfbp62) of S. anginosus to mucosal epithelial cells diminished significantly, and that the Dfbp62-infected mice showed considerably lower mortality and abscess formation rates, compared to the wild type S. anginosus-infected mice. Thus, a novel fibronectin binding protein of S. anginosus, Fbp62, could be an effective vaccine candidate for the S. anginosus-related oral cancer.
|
Research Products
(38 results)
-
[Journal Article] Subcutaneous tissue reactions against nano-apatite collagen composites.2012
Author(s)
Hatakeyama, W., Taira, M., Y., Kihara, H., Sasaki, M., Kimura, S., Kondo, H.
-
Journal Title
Nano Biomedicine
Volume: 4
Pages: 118-124
Peer Reviewed
-
-
[Journal Article] Proteome analyses of human macrophages exposed to low cytotoxic IC90 copper (2+) ions2011
Author(s)
Taira, M., Shimoyama, Y ., Kagiya, T., Sasaki, M., Nezu, T., Harada, H. and Kimura, S.
-
Journal Title
Dent. Mater. J.
Volume: 30
Pages: 293-299
Peer Reviewed
-
-
[Journal Article] Microscopic observations and inflammatory cytokine productions of human macrophage phagocytising submicron titanium particles2010
Author(s)
Taira, M., Kagiya, T., Harada, H., Sasaki, M., Kimura, S., Narushima, T., Nezu, T. and Araki, Y.
-
Journal Title
J. Mater. Sci. Mater. Med.
Volume: 21
Pages: 267-275
Peer Reviewed
-
[Journal Article] Relationship between oral status and prevalence of periodontopathic bacteria on the tongues of elderly individuals2010
Author(s)
Kishi, M., Ohara -Nemoto, Y., Takahashi, M., Kishi, K., Kimura, S. and Yonemitsu, M
-
Journal Title
J. Med. Microbiol.
Volume: 59
Pages: 1354 -1359
Peer Reviewed
-
[Journal Article] Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases2010
Author(s)
Ono, T., Ohara-Nemoto, Y., Shimoyama, Y., Okawara, H., Kobayakawa, T., Baba, T. T., Kimura, S. and Nemoto, T. K.:
-
Journal Title
Biol. Chem
Volume: 391
Pages: 1221-1232
Peer Reviewed
-
[Journal Article] Histological and TEMobservation of subcutaneous tissues exposed to particulate copper,nickel and titanium2010
Author(s)
Saitoh, S., Sasaki, K., Nezu, T., Taira, M., Shimoyama, Y. , Sasaki, M., Kimura, S.and Ishizeki, K
-
Journal Title
J. Oral Tissue Engin
Volume: 8
Pages: 102-106
Peer Reviewed
-
-
-
-
-
-
-
[Presentation] The pathogenic involvement of the fibronectin binding protein, Fbp62, in Streptococcus anginosus infection.2011
Author(s)
Sasaki, M., Kodama, Y., Shimoyama, Y ., Agato, S. and Kimura, S.
Organizer
International Union of Microbiological Societies 2011 Congress (IUMS 2011)
Place of Presentation
Sapporo, Japan
Year and Date
2011-09-07
-
[Presentation] Fbp62, fibronectin binding protein of Streptococcus anginosus involves the virulence in mouse infection.2011
Author(s)
Sasaki, M., Kodama, Y., Shimoyama, Y., Ishikawa, T. and Kimura, S.
Organizer
10th World Congress on Inflammation 2011
Place of Presentation
Paris, France
Year and Date
2011-06-26
-
[Presentation] Auto-catalytic propeptide processing facilitates the final hetero-catalytic maturation of glutamyl endopeptidase GluV8.2011
Author(s)
Ohara -Nemoto, Y., Rouf, S.M.A., Shimoyama, Y., Kimura, S. , Ono, T. and Nemoto, T.K.
Organizer
111th General Meeting of the American Society for Microbiology.
Place of Presentation
New Orleans, USA
Year and Date
2011-05-24
-
-
[Presentation] Rapid identification of Abiotrophia/Granulicatella species using by 16S rRNA based PCR and RFLP.2011
Author(s)
Shimoyama, Y., Sasaki, M., Ohara-Nemoto, Y., Nemoto, T. K., Ishikawa, T. and Kimura, S
Organizer
4th International Symposium for Interface Oral Health Science in Sendai
Place of Presentation
Sendai, Japan
Year and Date
2011-03-08
-
-
[Presentation] In vitro adherence of Candida albicans to acrylic resin with different surface status2011
Author(s)
Nomura, T., Suzuki, T., Furuya, J., Shimoyama, Y., Sasaki, M. and Kimura, S.
Organizer
4th International Symposium for Interface Oral Health Science in Sendai.
Place of Presentation
Sendai, Japan
Year and Date
2011-03-08
-
-
-
-
-
-
-
-
-
-
-
[Book] Pathogenesis and Treatment of Periodontitis2012
Author(s)
Kimura, S., Ohara-Nemoto, Y., Shimoyama, Y., Ishikawa, T., and Sasaki, M.
Total Pages
1-18
Publisher
In Periodontitis, InTech:Pathogenic factors of Porphyromonas gingivalis and the host difence mechanisms.
-
-
[Book] Rapid identification of Abiotrophia/Gr anulicatella species using by 16S rRNA based PCR and RFLP In Interface Oral Health Science 20112012
Author(s)
Shimoyama, Y., Sasaki, M. , Ohara -Nemoto, Y., Nemoto, T. K., Ishikawa, T. and Kimura, S.
Total Pages
206-208
Publisher
Springer Japan, Tokyo
-
-
[Book] In vitro adherence of Candida albicans to acrylic resin with different surface status. In Interface Oral Health Science 20112012
Author(s)
Nomura, T., Suzuki, T., Furuya, J., Shimoyama, Y. , Sasaki, M. and Kimura, S.
Total Pages
146-156
Publisher
Springer Japan, Tokyo
-
-
