2012 Fiscal Year Final Research Report
Histochemical and neurochemical studies on the biological basis of orofacial neuropathic pain
| Project/Area Number |
22592051
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUBOI Yoshiyuki 日本大学, 歯学部, 専任講師 (50246906)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 神経因性疼痛 / 難治性疼痛 / 三叉神経脊髄路核尾側亜核 / 側坐核 |
|---|
| Research Abstract |
Trigeminal nerve injury following oral surgery is known to elicit neuropathic pain in the orofacial region. In this project, we studied two mechanisms of orofacial neuropathic pain in rats. We analysed the role of protein kinase Cγ and the possible contribution of astroglial glutamine synthetase activity in the trigeminal spinal subnucleus caudalis to the experimentally-induced neuropathic pain. We also investigated aspects of the mechanisms of the regulation of dopaminergic activity in the nucleus accumbens, because painful events such as trigeminal nerve injury are known to strongly affect the dopaminergic activity in this area.
|
Research Products
(19 results)
-
-
-
[Journal Article] PKCgamma in Vc and C1/C2 is involved in trigeminal neuropathic pain.2011
Author(s)
Nakajima A, Tsuboi Y, Suzuki I, Honda K, Shinoda M, Kondo M, Matsuura S, Shibuta K, Yasuda M, Shimizu N, Iwata K.
-
Journal Title
J Dent Res.
Volume: 90
Pages: 777-781
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
