• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Histological analysis of annexin a5 function in the process ofperiodontal tissues regeneration.

Research Project

  • PDF
Project/Area Number 22592053
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionTsurumi University

Principal Investigator

SHIMADA Akemi  鶴見大学, 歯学部, 助教 (00339813)

Co-Investigator(Kenkyū-buntansha) NIFUJI Akira  鶴見大学, 歯学部, 教授 (00240747)
Project Period (FY) 2010 – 2012
Keywords歯根膜 / 組織幹細胞 / アネキシン a5
Research Abstract

Localization and function of Annexin a5 (Anxa5) expressing cells in the periodontal tissues were histologically analyzed. At 1 week after birth, Anxa5 was expressed at the area for tooth root formation. At 4 weeks after birth, Anxa5 was expressed in apex and cervical areas of tooth roots, cementblasts, periosteum, and perivascular areas. In the process of periodontal regeneration after tooth replantation at 6 weeks after birth, Anxa5 positive cells were markedly increased in the periodontal tissues at 3 days after replantation. At 8 weeks after birth, Anxa5 deficient mice showed less cement formation at the root apexes and wider periodontal ligament than those of wild mice. On the other hand, adult long bones of Anxa5 deficient mice showed larger bone formation at the insertionsites of tendon and ligament than those of wild mice. These results suggest that Anxa5 is involved in the process of development, remodeling and regeneration of hard tissues including surrounding soft tiss

  • Research Products

    (14 results)

All 2013 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (11 results)

  • [Journal Article] Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development.2013

    • Author(s)
      Ideno H, Shimada A, Imaizumi K, Kimura H, Abe M, Nakashima K, Nifuji A.
    • Journal Title

      Gene Expr Patterns.

      Volume: 13 Pages: 84-90

    • Peer Reviewed
  • [Journal Article] Ideno H, Shimada A, Nifuji A, Abe M. Negligible immunogenicity of terminally differentiated cells derived from iPSCs or ESCs.2013

    • Author(s)
      Araki R, Uda M, Hoki Y, Sunayama M, Nakamura M, Ando S, Sugiura M
    • Journal Title

      Nature

      Volume: 494 Pages: 100-104

    • Peer Reviewed
  • [Journal Article] Improved methods for detection of β-galactosidase (lacZ) activity in hard tissue.2012

    • Author(s)
      Shimada A, Komatsu K, Nakashima K, Poschl E, Nifuji A.
    • Journal Title

      Histochem Cell Biol.

      Volume: 137 Pages: 841-847

    • Peer Reviewed
  • [Presentation] Limited and comparable immunogenicity of terminally differentiated cells derived from both iPSCs and ESCs.2012

    • Author(s)
      Uda M, Araki R, Hoki Y, Sayama M, Nakamura M, Andou S, Sugiura M, Ideno H,Shimada A, Nifuji A, Abe M.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、福岡.
    • Year and Date
      2012-12-13
  • [Presentation] Expression of three histone 3 lysine 9 methyltransferases during development ofmouse molar.2012

    • Author(s)
      Kamiunten T, Shimada A, Ideno H, Nakamura Y, Kimura H, Nakashima K, Nifuji A.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、福岡.
    • Year and Date
      2012-12-13
  • [Presentation] Soluble factors may mediate signals from tendons to bone.2012

    • Author(s)
      Wada S, Shimada A, Ideno H, Nakamura Y, Nakashima K, Nifuji A.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、福岡.
    • Year and Date
      2012-12-13
  • [Presentation] Histone 3 lysine 9 methyltransferases G9a,GLP and SETDB1 are predominantly expressed in the prehypertrophc chondrocytes during thegrowth plate chondrocyte development.2012

    • Author(s)
      Ideno H, Shimada A, Kamiunten T,Imaizumi K, Kimura H, Nakashima K, Nifuji A.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国 際会議場、福岡.
    • Year and Date
      2012-12-11
  • [Presentation] アレンドロネートの 細胞内取込みによる骨形成の促進.2012

    • Author(s)
      小松浩一郎、島田 明美、出野 尚、柴田 達 也、中島 和久、二藤 彰.
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザ ホテル、東京.
    • Year and Date
      2012-07-19
  • [Presentation] Pre-incubation of whole teeth in collagen gel enrich progenitor cells of mouseperiodontal ligament.2011

    • Author(s)
      Shimada A, Shibata T, Komatsu K, Ideno H, Nifuji A.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜会議セン ター、神奈川
    • Year and Date
      2011-12-13
  • [Presentation] Nifuji A. Annexin a5Expression Regulates Periodontal Tissue andCementum Formation.2011

    • Author(s)
      Shimada A, Komatsu K, Nakashima K, Amizuka N, Brachvogel B
    • Organizer
      2011 Annual Meeting of ASBMR
    • Place of Presentation
      San Diego, California, USA.
    • Year and Date
      2011-09-19
  • [Presentation] 歯周組織形成過 程におけるAnnexin a5の発現と機能2011

    • Author(s)
      島田 明美、小松浩一郎、中島 和久、網塚 憲生、Bent Brachvogel、二藤 彰
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪府、大 阪国際会議場
    • Year and Date
      2011-07-28
  • [Presentation] エンドサイトーシスを介した骨芽 細胞の生存と分化に対するアレンドロネートの影 響.2010

    • Author(s)
      小松浩一郎、島田 明美、出野 尚、柴田 達 也、二藤 彰.
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル,東京.
    • Year and Date
      2010-07-23
  • [Presentation] 硬組織に おけるβ-Galactosidase(LacZ)レポーター遺伝子 発現検出法の検討.2010

    • Author(s)
      島田 明美、小松浩一郎、二藤 彰.
    • Organizer
      第28回日本骨代謝学会学術集 会
    • Place of Presentation
      京王プラザホテル,東京
    • Year and Date
      2010-07-23
  • [Presentation] Collagen Gel Culture Accelerates Proliferation of Mouse Periodontal Ligament Cells.2010

    • Author(s)
      Shimada A, Shibata T, KomatsuK, Nifuji A.
    • Organizer
      88thGeneral Session & Exhibition of the IADR
    • Place of Presentation
      Centre Convencions Internacional Barcelona, Spain.
    • Year and Date
      2010-07-17

URL: 

Published: 2014-08-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi