2012 Fiscal Year Final Research Report
Mechanisms of transactivation of EGF receptor in submandibular gland rudiments by HGF
| Project/Area Number |
22592054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOYAMA Noriko 朝日大学, 歯学部, 准教授 (60367563)
HAYASHI Toru 朝日大学, 歯学部, 助教 (10454266)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 上皮間葉相互作用 / 分枝形態形成 / EGF / HGF / 器官培養 / 顎下腺原基 / 唾液腺 |
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| Research Abstract |
HGFisknowntoregulatebranchingmorphogenesisoffetalmousesubmandibulargland(SMG).However,themechanismsofregulationofbranchingmorphogenesisarelargelyunknown.HGFweaklystimulatesbranchingmorphogenesisandinducedmorphologicalchangesofsurfaceofbudsofSMGrudiments.Byusingmesenchyme-freeepithelialculturesystem,wecouldobservethatHGFstimulatecleftformationofSMGepithelium.HGFalsoinducedEGFreceptor(ErbB1)phosphorylationbytreatmentofculturedSMGrudimentswithHGF.TheseresultsimplythatEGF/EGFreceptorsystemisresponsible,atleastinpart,forthestimulatoryeffectofHGFonbranchingmorphogenesisofculturedSMGrudimentsandcleftformationofSMGepithelium
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