2012 Fiscal Year Final Research Report
Roles of sphingolipid metabolism on cell death by necroptosis
| Project/Area Number |
22592060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YOKOYAMA Miki 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (70191533)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 口腔生化学 / 細胞死 |
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| Research Abstract |
Sphingosine kinase (SPHK), which catalyzes the phosphorylation of sphingosine to generate sphingosine-1-phosphate, has two mammalian isotypes, SPHK1 and SPHK2. Both isozymes are promising anti-cancer therapeutic targets. In this study, we found that sphingosine and SG-12, a synthetic analogue of sphingosine that acts as a SPHK2 inhibitor, induce cell death via phosphorylation by SPHK1 and SPHK2, respectively. The present results revealed the novel anti-cancer potential of a sphingosine analogue in the pathological setting where SPHK2 is upregulated.
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Research Products
(15 results)
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[Journal Article] Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities2012
Author(s)
Miki Hara-Yokoyama, Mutsuko Kukimoto-Niino, Kazue Terasawa, Satoru Harumiya, Katarzyna A. Podyma-Inoue, Nobumasa Hino, Kensaku Sakamoto, Satsuki Itoh, Noritaka Hashii, Yoko Hiruta, Nana Kawasaki, Chiemi Mishima-Tsumagari, Yoko Kaitsu, Tomoko Matsumoto, Motoaki Wakiyama, Mikako Shirouzu, Takeshi Kasama, Hiroshi Takayanagi, Naoko Utsunomiya-Tate, Kiyoshi Takatsu, Toshiaki Katada, Yoshio Hirabayashi, Shigeyuki Yokoyama and Masaki Yanagishita
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Journal Title
Structure
Volume: 20
Pages: 1-11
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[Journal Article] Structural basis of interleukin-5 dimerrecognition by its α receptor2012
Author(s)
Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Ikutani M, Takaki S, Sakamoto K, Hara-Yokoyama M, Shirouzu M, Takatsu K, Yokoyama S
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Journal Title
Protein Sci
Volume: 21
Pages: 850-64
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[Journal Article] Pocket epithelium in the pathological setting for HMGB1 release2011
Author(s)
Ebe N, Hara-Yokoyama M, Iwasaki K, Iseki S, Okuhara S, Podyma-Inoue KA, Terasawa K, Watanabe A, Akizuki T, Watanabe H, Yanagishita M, Izumi Y
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Journal Title
Journal of Dental Reserch
Volume: 90
Pages: 235-40
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[Journal Article] Survival signals of hepatic stellate cells in liver regeneration are regulated by glycosylation changes in rat vitronectin, especially decreased sialylation2010
Author(s)
Sano K, Miyamoto Y, Kawasaki N, Hashii N, Itoh S, Murase M, Date K, Yokoyama M, Sato C, Kitajima K, Ogawa H
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Journal Title
J Biol Chem
Volume: 285
Pages: 17301-17309
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