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2012 Fiscal Year Final Research Report

Analysis of mouse teeth hyperplasia and gut tissue enlargement by mutation of transcription factor Bcl11b

Research Project

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Project/Area Number 22592062
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionNiigata University

Principal Investigator

MISHIMA Yukio  新潟大学, 医歯学系, 准教授 (30142029)

Co-Investigator(Kenkyū-buntansha) OBATA Miki  新潟大学, 医学部, 教務職員 (00420307)
Project Period (FY) 2010 – 2012
Keywords過剰歯形成 / 腸管組織の肥厚 / 転写因子Bcl11b/BCL11B / p^53 / Mdm2/HDM2
Research Abstract

Bcl11b/BCL11B is a C_2H_2 zinc finger transcription factor that acts as a haploinsufficient tumor suppressor. Mutations and deletion in the human orthologue BCL11B have been identified in human T-cell acute lymphoblastic leukemia (T-ALL) and a mouse model of thymic lymphomas. We have examined whether or not BCL11B directly affects the p^53 signaling pathway including HDM2, an ubiquitin ligase for p^53 degradation. This is because that the p^53 pathway regulates cell proliferation and the response to DNA damages to maintain genome integrity. We have obtained the results that BCL11B binds to human HDM2-P2 promoter by ChIP (chromatin immuno-precipitation) assay and inhibits HDM2 expression in a p^53-dependent manner. These date suggest that BCL11B affects the activity of the p53-HDM2 feedback loop. This may be a mechanism for the leukemic transformation in T-ALL and for the impairment of incisor development and the enlargement of intestine crypts in Bcl11b S826G/KO mouse.

  • Research Products

    (18 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (12 results)

  • [Journal Article] Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis2012

    • Author(s)
      R. Go, K. Takizawa, S. Hirose, Y. Katsuragi,Y. Aoyagi, S, Y. Mishima and R. Kominami
    • Journal Title

      Leukemia Research

      Volume: 36 Pages: 1035-1040

    • DOI

      doi:10.1016/j.leukres.2012.04.028

    • Peer Reviewed
  • [Journal Article] BCL11B tumor suppressor inhibits HDM2 expression in a p^53-dependent manner2012

    • Author(s)
      M. Obata, R. Kominami and Y. Mishima
    • Journal Title

      Cellular Signalling

      Volume: 24 Pages: 1047-1052

    • DOI

      doi:10.1016/j.cellsig.2011.12.026

    • Peer Reviewed
  • [Journal Article] Bcl11b heterozygosity leads to age-related hearing loss and degeneration of outer hair cells of the mouse cochlea2011

    • Author(s)
      H. Okumura, Y. Miyasaka, Y. Morita, T. Nomura, Y. Mishima, S. Takahashi and R. Kominami
    • Journal Title

      Experimental Animals

      Volume: 60 Pages: 355-361

    • Peer Reviewed
  • [Journal Article] Bcl11b heterozygousity promotes clonal expansion and differentiation arrest of thymocytes in γ-irradiated mice2010

    • Author(s)
      R. Go, S. Hirose, S. Morita, T. Yamamoto, Y. Katsuragi, Y. Mishima and R. Kominami
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 1347-1353

    • DOI

      doi:10.1111/j.1349-7006.2010.01546.x

    • Peer Reviewed
  • [Journal Article] Clonally expanding thymocytes having lineage capability in γ-ray induced mouse atrophic thymus2010

    • Author(s)
      T. Yamamoto, S. Morita, E. Go, M. Obata, Y. Katsuragi, Y. Fujita, Y. Maeda, M. Yokoyama, Y. Aoyagi, H. Ichikawa, Y. Mishima and R. Kominami
    • Journal Title

      International Journal of Radiation Oncology. Biology. Physics

      Volume: 77 Pages: 235-243

    • DOI

      doi:10.1016/j.ijrobp.2009.11.005

    • Peer Reviewed
  • [Journal Article] Cell of origin in radiation-induced premalignant thymocytes with differentiation capability in mice conditionally losing one Bcl11b allele

    • Author(s)
      R. Go, S. Hirose, Y. Katsuragi, M. Obata, M. Abe, Y. Mishima, K. Sakimura and R.Kominami
    • Journal Title

      Cancer Science

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] ヒトT細胞急性リンパ芽球性白血病で見いだされたBCL11B突然変異はp53依存性にHDM2プロモーター活性の抑制効果を阻害する2012

    • Author(s)
      小幡美貴、木南凌、三嶋行雄
    • Organizer
      第35回日本分子生物学会年
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
  • [Presentation] 転写因子Bcl11bはマウス上顎切歯におけるエナメル芽細胞前駆細胞の恒常性に寄与する2012

    • Author(s)
      葛城美徳、安楽純子、中富満城、依田浩子、三嶋行雄、櫻庭喜行、権藤洋一、高木律男、大島勇人、木南凌
    • Organizer
      第35回日本分子生物学会年
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
  • [Presentation] 放射線照射後の腸上皮におけるBcl11bの働き2012

    • Author(s)
      葛城美徳、坂牧僚、小幡美貴、三嶋行雄、大塚健介、木南凌
    • Organizer
      第55回日本放射線影響学会
    • Place of Presentation
      仙台
    • Year and Date
      2012-09-07
  • [Presentation] BCL11B inhibits HDM2 expression in a p^53-denpendent manner2011

    • Author(s)
      小幡美貴、木南凌、三嶋行雄
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
  • [Presentation] Bcl11b transcription factor controls the formation and maintenance of ameloblast-lineage cells in mouse adult maxillary incisor2011

    • Author(s)
      葛城美徳、安楽純子、中富満城、井出浩子、 三嶋行雄 、桜場喜行、権藤洋一、高木律夫、大島勇人、木南凌
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
  • [Presentation] Bcl11bの片アリル欠損はγ線照射後のマウス小腸上皮幹細胞の増殖を促進する2011

    • Author(s)
      葛城美徳、坂牧僚、小幡美貴、三嶋行雄、木南凌
    • Organizer
      第54回日本放射線影響学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2011-11-17
  • [Presentation] 転写因子Bcl11bはp^53経路を介して細胞増殖を抑制する2011

    • Author(s)
      小幡美貴、坂牧僚、木南凌、三嶋行雄
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
  • [Presentation] Loss of a Bcl11b allele promotes proliferation of stem cells in the mouse small intestine after γ-irradiation2011

    • Author(s)
      葛城美徳、小幡美貴、三嶋行雄、木南凌
    • Organizer
      第14回国際放射線研究会議
    • Place of Presentation
      ワルシャワ、ポーランド
    • Year and Date
      2011-08-28
  • [Presentation] p27/p57遺伝子内のBcl11b依存性転写活性化及び抑制化制御配列2010

    • Author(s)
      小幡美貴、西川敦、木南凌、三嶋行雄
    • Organizer
      第83回日本生化学会大会/第33回日本分子生物学会年会合同学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
  • [Presentation] Bcl11bは腸上皮細胞の恒常性を制御する大腸がん抑制遺伝子である2010

    • Author(s)
      葛城美徳、坂牧僚、小幡美貴、郷梨江香、三嶋行雄、権藤洋一、落合雅子、中釜斉、木南凌
    • Organizer
      第83回日本生化学会大会/第33回日本分子生物学会年会合同学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
  • [Presentation] Bcl11b is an intestinal tumor suppressor that controls intestinal cell homeostasis2010

    • Author(s)
      坂牧僚、葛城美徳、小幡美貴、落合雅子、中釜斉、権藤洋一、三嶋行雄、木南凌
    • Organizer
      第69回 日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
  • [Presentation] Bcl111b heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in gamma-irradiated mice2010

    • Author(s)
      郷梨江香、広瀬智史、葛城美徳、三嶋行雄、木南凌
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22

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Published: 2014-08-29  

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