2012 Fiscal Year Final Research Report
Functional analysis of the progress suppressor of mucosa-associated lymphoid tissue 1 with oral carcinomas
| Project/Area Number |
22592080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 癌 / MALT1 / 細胞増殖 |
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| Research Abstract |
Mucosa-associated lymphoid tissue 1 (MALT1) is a major player in lymphocyte activation and modulates NF-kB signaling pathways through its scaffolding function. We studied the role of MALT1 in the oral carcinoma cells. In the first study, we analyzed alterations of protein expression in response to MALT1 in oral carcinoma cells with proteomics analysis. Four different keratins, K8/18 and K5/14 were identified in MALT1-expressing and-negative HSC2 cells. K5/14 is an important marker in the tumorigenic process, distinguishing normal from tumor cells, and decreased K5/14 expression correlates with tumorigenic progression.
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Research Products
(18 results)
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[Presentation] Progression/metastasis of xenografted oral cancer cell-lines in mouse tongue.2012
Author(s)
Y. Soeno, Y. Shirako, K. Fujita, Y. Taya, Y. Shimazu, K. Nakau, K. Sato, T. Chiba, K. Imai, T. Aoba.
Organizer
41st Annual Meeting & Exhibition of the AADR, March 21-24
Place of Presentation
Tampa, FL, USA.
Year and Date
20120000
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