2012 Fiscal Year Final Research Report
Cross-talk between innate-immunological responses and oral oncogenesis.
| Project/Area Number |
22592081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
YASUDA Motoaki 北海道大学, 大学院・歯学研究科, 准教授 (90239765)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHINO Fumihiro 北海道大学, 大学院・歯学研究科, 准教授 (50301891)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 実験腫瘍学 |
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| Research Abstract |
Approximately 50% decreased protein expression was observed for3’UTR of HIF-1 containing constructs compared to the control vector. In particular, a highly-aggressive breast cancer cell line MDA-MB-453 demonstrated a higher protein expression compared to a less-aggressive breast cancer cell line MCF7. It is plausible that 3’UTR dependent degradation of HIF-1a mRNA is repressed in several cancer cells which indicate malignant phenotypes. We also found the same phenotype in oral squamous cell carcinoma cells. Thus, 3’UTR dependent regulation of mRNA degradation might play an important role in the progression (vascular induction, invasion oreptherial-mesenchymal transition) of oral cancers.
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