2012 Fiscal Year Final Research Report
Study on the regulation mechanism of oxidative stress for treatment of dry mouth in Sjogren's syndrome
| Project/Area Number |
22592085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Niigata University |
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Principal Investigator |
SOHDA Miwa 新潟大学, 医歯学系, 助教 (20258528)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 歯学 / 細胞組織 / 酸化ストレス / 唾液腺 |
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| Research Abstract |
Sjogren’s syndrome is a chronic inflammatory autoimmune disorder that affects mainly salivary and lacrimal gland, resulting in dry mouth and dry eyes symptoms. In this study, to understand the regulatory mechanism of inflammation in salivary gland, oxidative stress response was investigated using human submaxillary salivary gland A-253 cells. A whole human genome micro-array analysis showed that the expression levels of pro-inflammatory cytokines such as IL-6, IL-18 and CXCL1 were increased in H2O2 treated cells compared with control cells. While, anti-inflammatory cytokine IL-11 was up-regulated in H2O2 treated cells. These results suggest that the target tissue itself might have a role on regulation of peripheral inflammation. IL-11 might be a candidate molecule for substitution therapy. Furthermore, a soluble isoform of IL-17 receptor A (IL-17RA) was identified in human salivary gland. IL-17 was supposed to a key molecule of inflammatory disorders such as Sjogren’s syndrome, rheumatoid arthritis and Crohn’s disease. The soluble isoform of IL-17 RA could be an endogenous antagonist against the IL-17 signaling.
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