2012 Fiscal Year Final Research Report
Pathological analysis of epithelial cells in periodontitis
| Project/Area Number |
22592086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUKUMA Yutaka 長崎大学, 大学院・医歯薬学総合研究科, 教務職員 (50253688)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKUBA Takayuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30264055)
OKAMOTO Kuniaki 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (10311846)
NISHISHITA Kazuhisa 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20237697)
SAKAI Eiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10176612)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 歯周病 / 上皮細胞 / リソソーム |
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| Research Abstract |
Periodontitis is a bacterial infectious disease that destroys gingival epithelial cells, and develops inflammation of immune-related cells. However, pathological studies on epithelial cells in periodontitis have been less frequently performed compared to those of immune-related cells. In this study, we focused on lysosomal abnormalities, because gene mutants of lysosomal proteins such as cathepsin C and Lyst causes severe periodontal diseases in human．Therefore, we analyzed epithelial cells in cathepsin C deficient mice and Lyst mutant mice (beige mouse) infected by Porphyromonas gingivalis, a major periodontal pathogen, in order to clear the physiological and pathological roles of epithelial cells in periodontitis.
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