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2012 Fiscal Year Final Research Report

Inhibition of NFκB activity by MALT1 and its involvement in phenotypic alterations of oral carcinoma cells

Research Project

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Project/Area Number 22592103
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionThe Nippon Dental University

Principal Investigator

IMAI Kazushi  日本歯科大学, 生命歯学部, 教授 (10328859)

Co-Investigator(Kenkyū-buntansha) CHIBA Tadashige  日本歯科大学, 生命歯学部, 准教授 (60350138)
MORIKAWA Masako  日本歯科大学, 生命歯学部, 准教授 (80095265)
Project Period (FY) 2010 – 2012
Keywords口腔癌 / MALT1
Research Abstract

The present study examined a role of mucosa-associated lymphoid tissue 1 (MALT1), whose expression is inactivated in oral carcinomas with worse prognosis, in oral carcinoma cells and its involvement in phenotypic alteration of the cells by the microarray and proteomic analyses. MALT1 down-regulated expression of genes in the TGF-ss and EGF pathways, alternated keratin species involved in aggressive feature of carcinoma cells, and suppressed proliferation and migration of the cells. Furthermore, E-cadherin-mediated carcinoma cell-cell adhesion machinery, which was also strongly down-regulated by MALT1, was rapidly obstructed with progression of oral carcinomas.

  • Research Products

    (13 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (6 results) Book (1 results)

  • [Journal Article] 口腔癌進展のメカニズムと分子標的薬2013

    • Author(s)
      今井一志、須藤遥、前田元太、千葉忠成
    • Journal Title

      歯学

      Volume: 100 Pages: 177-181

  • [Journal Article] Progression of oral squamous cell carcinoma accompanied with reduced E-cadherin expression but not cadherin switch.2012

    • Author(s)
      Hashimoto T, Soeno Y, Maeda G, Taya Y, Aoba T, Nasu M, Kawashiri S, Imai K.
    • Journal Title

      PLoS One

      Volume: 7 Pages: e47899

    • DOI

      DOI:10.1371/journal.pone.0047899

    • Peer Reviewed
  • [Journal Article] Concomitant loss of p120-catenin and β-catenin membrane expression and oral carcinoma progression with E-cadherin reduction.

    • Author(s)
      Sasaya K, Sudo H, Maeda G, Kawashiri S, Imai K.
    • Journal Title

      PLoS One

      Volume: (in press)

    • URL

      http://www.plosone.org/home.action

    • Peer Reviewed
  • [Journal Article] Proteomic identification of keratin alterations with enhanced proliferation of oral carcinoma cells by loss of mucosa-associated lymphoid tissue 1 expression.

    • Author(s)
      Kawamoto Y, Ohyama Y, Chiaba T, Yagishita H, Sakashita H, Imai K.
    • Journal Title

      Int J Oncol

      Volume: (in press)

    • URL

      http://www.spandidos-publications.com/ijo/

    • Peer Reviewed
  • [Journal Article] Inhibition of TGF- and EGF pathway gene expression and migration of oral carcinoma cells by mucosa-associated lymphoid tissue 1.

    • Author(s)
      Ohyama Y, Kawamoto Y, Chiba T, Maeda G, Sakashita H, Imai K
    • Journal Title

      Br J Cancer

      Volume: (in press)

    • DOI

      DOI:10.1038/bjc2013.307

    • Peer Reviewed
  • [Journal Article] Single nucleotide polymorphisms of mucosa-associated lymphoid tissue 1 n oral carcinoma cells and fibroblasts.

    • Author(s)
      Oyama G, Midorikawa T, Matsumoto Y, Takeyama M, Yamada K, Nozawa T, Morikawa M, Imai K.
    • Journal Title

      Odontology

      Volume: (in press)

    • DOI

      DOI:10.1007/s10266-12-0079-9

    • Peer Reviewed
  • [Presentation] MALT1-responsive keratin rearrangement and proliferation of oral carcinoma cells.2013

    • Author(s)
      Kawamoto H, Ohyama Y, Chiba T, Yagishita H, Sakashita H, Imai K.
    • Organizer
      IADR/AADR/CADR General Session and Exhibition
    • Place of Presentation
      Seattle, WA,USA
    • Year and Date
      20130320-23
  • [Presentation] Profiling and network analysis of MALT1-responsive gene datasets in SCC.2013

    • Author(s)
      Ohyama Y, Kawamoto H, Chiba T, Maeda G, Sakashita H, Imai K.
    • Organizer
      IADR/AADR/CADR General Session and Exhibition
    • Place of Presentation
      Seattle,WA,USA
    • Year and Date
      20130320-23
  • [Presentation] Progression/metastasis of xenografted oral cancer cell-lines in mouse tongue.2012

    • Author(s)
      Soeno Y, Shirako Y, Fujita K, Taya Y, Shimazu Y, Nakau K, Sato K, Chiba T, ImaiK,AobaT
    • Organizer
      41st Annual Meeting & Exhibition of the AADR
    • Place of Presentation
      Tampa,FL,USA
    • Year and Date
      20120321-24
  • [Presentation] 口腔癌の進展にはカドヘリンスイッチではなく、E-カドヘリンの発現低下が関連する2012

    • Author(s)
      橋本孝志、添野雄一、田谷雄二、青葉孝昭、那須優則、前田元太、須藤遥、千葉忠成、今井一志
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      郡山市
    • Year and Date
      2012-09-15
  • [Presentation] 口腔癌におけるp120カテニンとβカテニン発現の免疫組織学的解析2012

    • Author(s)
      笹谷和伸、前田元太、須藤遥、千葉忠成、今井一志
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      郡山市
    • Year and Date
      2012-09-15
  • [Presentation] 口腔扁平上皮癌細胞におけるMALT1誘導タンパク質のプロテオーム解析2011

    • Author(s)
      川本幸寛、大山嘉人、千葉忠成、坂下英明、今井一志
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岐阜市
    • Year and Date
      20110100
  • [Book] Chapter 7: Cadherin expression and progression of squamous cell carcinomas of the oral cavity. In Squamous Cell Carcinom2012

    • Author(s)
      Imai K, Maeda G, Chiba T
    • Total Pages
      121-136
    • Publisher
      Li X,,ed

URL: 

Published: 2014-08-29  

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