The effect of chlorhexidine to improve dentin bond durability

2013 Fiscal Year Final Research Report

• Project/Area Number: 22592114
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: HIRAISHI Noriko 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (20567747)
• Project Period (FY): 2010-04-01 – 2013-03-31
• Keywords: クロルヘキシジン / 歯科材料 / 象牙質 / 親水性 / 接着歯学

Research Abstract

I studied the effect of chlorhexidine incorporation into experimental dentin adhesives with different hydrophilicities on the chlorhexidine release and the microtensile bond strength to dentin after 24 h and 14 months after specimen preparation. The more chlorhexidine released the more hydrophilic resin co-monomers. Significant reduction in bond strength was observed in all adhesive groups, except for chlorhexidine-containing most hydrophobic adhesive. Also, MMA-based resin was used to measure chlorhexidine-release from resin cement by means of HPLC, and antibacterial effect against Streptococcus mutans and Enterococcus faecalis. The 3.0 and 4.0% chlorhexidine-incorporated cement exhibited chlorhexidine release for 5 weeks; however, more than 98% of chlorhexidine was retained in resin matrix. The 3.0 and 4.0% chlorhexidine-incorporated resin cement possessed prolonged chlorhexidine release and antibacterial properties for 2 weeks.

Research Products

• [Journal Article] Effect of natural cross-linkers incorporation in a self-etching primer on dentine bond strength (2012)
  • Author(s): Islam S, Hiraishi N, Nassar M, Yiu C, Otsuki M, Tagami J
  • Journal Title: J Dent Volume: 40(12) Pages: 1052-92
  • DOI: 10.1016/j.jdent.2012.08.015
• [Journal Article] Effect of chlorhexidine incorporation into dental adhesive resin on durability of resin-dentin bond (2012)
  • Author(s): Yiu CK, Hiraishi N, Tay FR, King NM
  • Journal Title: J Adhes Dent Volume: 14(4) Pages: 355-62
  • DOI: 10.3290/j.jad.a25674
• [Journal Article] Chlorhexidine release and antibacterial properties of chlorhexidine-incorporated polymethyl methacrylate-based resin cement (2010)
  • Author(s): Hiraishi N, Yiu CK, King NM, Tay FR
  • Journal Title: J Biomed Mater Res B Appl Biomater Volume: 94(1) Pages: 134-40
  • DOI: 10.1002/jbm.b.31633
• [Presentation] Glutathione Detoxification of 2-hydroxyethylmethacrylate and Its Effect on Bond Strength (2013)
  • Author(s): Nassar Mohannad, Hiraishi Noriko, Islam Md.Sofiqul, Yukihiko Tamurad, Masayuki Otsukia, Shohei Kasugaie, Keiichi Ohyad, Junji Tagamia, Tay Flanklin
  • Organizer: IADR/AADR/CADR General Session, (Oral presentation)
  • Place of Presentation: Washington Convention Center, Seattle, Washington. USA
  • Year and Date: 20130320-23
• [Presentation] Effect of Cross-linker on Resin-dentin Bond Strength of Self-etch Adhesive (2012)
  • Author(s): Islam Sofiqul, Hiraishi Noriko, Otsuki Masayoki, Tagami Junji
  • Organizer: The 26th International Association of Dental Research South East Asia Division, (Oral presentation)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20121103-04
• [Presentation] Effect of Incorporation of Hesperidin in a Self-etching Primer on Dentin Bond Strength (2011)
  • Author(s): Islam Sofiqul, Hiraishi Noriko, Otsuki Masayoki, Tagami Junji
  • Organizer: The 135th meeting of Japanese society of conservative dentistry, (Oral presentation)
  • Place of Presentation: Osaka international house foundation, Osaka, Japan
  • Year and Date: 20111020-21
• [Presentation] Effect of Grape Seeds on Stabilization of Collagen and Remineralization of the Root Dentin Lesion (2011)
  • Author(s): Islam Sofiqul,Hiraishi Noriko,Otsuki Hasayuki,Tagami Junji
  • Organizer: The 134th meeting of Japanese society of conservative dentistry, (Oral presentation)
  • Place of Presentation: Tokyo Disney resort Tokyo Bay Club Resort Hotel, Chiba, Japan
  • Year and Date: 20110609-10
• [Presentation] Effect of Hesperidin Incorporation into the Primer of a Self-etching Adhesive on Micro Tensile Bond Strength to Dentin (2011)
  • Author(s): Islam Md. Sofiqul, Hiraishi Noriko, Otsuki Masayoki, Tagami Junji
  • Organizer: The 4th International Congress on Adhesive Dentistry, (Oral & poster presentations)
  • Place of Presentation: Millennium Seoul Hilton hotel, Seoul, Korea
  • Year and Date: 20110415-17
• [Presentation] クロルヘキシジン含有歯科メチルメタクリレートセメントの長期性抗菌作用 (2010)
  • Author(s): 平石典子、田上順次
  • Organizer: 第133回日本歯科保存学会
  • Place of Presentation: 岐阜
  • Year and Date: 20101028-29