2012 Fiscal Year Final Research Report
Relations between sensation and innervation of dental pulp in patients with hereditary sensory and autonomic neuropathy(HSAN).
| Project/Area Number |
22592117
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Conservative dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
MIWA Zenzo 東京医科歯科大学, 歯学部附属病院, 講師 (30157705)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SATO Tetsuji 鶴見大学, 歯学部, 教授 (10162447)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KAKINO Satoko 東京医科歯科大学, 歯学部附属病院, 医員 (30516307)
INOUE Kouji 鶴見大学, 歯学部, 助教 (40097308)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 先天性無痛無汗症 / 歯髄電気診(EPT) / pre-pain感覚 / 神経支配 / 免疫染色法 / 透過光光電脈波法(TLP) |
|---|
| Research Abstract |
By electrical pulp tester (EPT), patients with hereditary sensory and autonomic neuropathy (HSAN-IV)cases did not feel any sensation at all in their teeth, but HSAN-V cases felt the pre-pain sensation similar to a normal person. Only a few myelinated fibers were observed in HSAN-IVcases, on the other hand, many fibers were identified in the dental pulp of patients withHSAN-V. The present result shows that remarkably reduced pulpal innervation might induce congenitalinsensitivity to pain in HSAN-IV.
|
