Development of new treatment in replantation of teeth used at hyperbaric oxygen therapy

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592143
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TAKAHASHI Toshiyuki 東京医科歯科大学, 大学院・医歯学総合研究 科, 助教 (80360923)
• Co-Investigator(Kenkyū-buntansha): UENO Toshiaki 東京医科歯科大学, 大学院・医歯学総合研究 科, 准教授 (30292981) ; KATO Tsuyoshi 東京医科歯科大学, 医学部付属病院, 助教
• Project Period (FY): 2010 – 2012
• Keywords: 高気圧酸素治療 / 歯牙再植

Research Abstract

The aim of the present study was to investigate the effect of hyperbaric oxygen (HBO) on the healing of the replanted molar in rat. Group 1 consisted of rats which underwent HBO, and Group 2 consisted of rats receiving no treatment. Group2 rats were given HBO (100% oxygen at 2.5 atmosphere absolute) for 120 minutes per day for five days, beginning the day of surgery. The experimental tissues in both groups were removed at 7 day after operation. By histological evaluation, the HBO therapy seemed to increased microvessel density and fibroblast in periodontal tissues of replanted molar. It was suggested that HBO therapy has a positive effects on the healing of the replantedmolar in rat.