Development of bone resorption inhibitors/drugs targeting signaling molecule PICK1

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592147
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Osaka University
• Principal Investigator: AKASHI Yoshihiro 大阪大学, 歯学部附属病院, 医員 (60571049)
• Co-Investigator(Kenkyū-buntansha): EGUSA Hiroshi 大阪大学, 大学院・歯学研究科, 助教 (30379078)
• Research Collaborator: KAMANO Yuya 大阪大学, 大学院・歯学研究科, 大学院生
• Project Period (FY): 2010 – 2012
• Keywords: 破骨細胞 / カルシニューリン / PICK1 / シグナル伝達

Research Abstract

Novel molecular mechanisms and molecular targets for osteoclastogenesis could form the basis for effective therapeutic strategies against alveolar bone resorption. We previously identified PICK1 (protein interacting with C kinase) as a novel calcineurin B-binding protein that modulates NFAT activity in neuron-like PC12 cells. In this study, we found that PICK1 binds to calcineurin B in osteoclast progenitor cells and promotes osteoclast differentiation via the activation of calcineurin-NFAT signaling. The novel molecular target PICK1 may be useful for therapeutic strategies against alveolar bone resorption in prosthetic treatments.

Research Products

• [Presentation] PICK1 regulates osteoclastogenesis by binding to calcineurin B (2012)
  • Author(s): Kamano Y, Egusa H, Saeki M, Iida T, Uraguchi S, Yatani H
  • Organizer: The 90th IADR General Session
  • Place of Presentation: Iguacu Falls,Brazil
  • Year and Date: 2012-06-20
• [Remarks] 江草 宏.大阪大学功績賞,2011年 8月 1日.
• [Remarks] 江草 宏.国際歯科研究学会(IADR)Distinguished Scientist Award (Young Investigator Award),2012年6月20日.
• [Remarks] 鎌野優弥.Finalist,IADR Arthur R. Frechette 若手歯科補綴学研究者賞,2012年6月21日