The function of miRNAs in the atrophy of tongue and masticatory muscles with aging and searching for the treatment

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592171
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Tsurumi University
• Principal Investigator: SUGA Takeo 鶴見大学, 歯学部, 講師 (40247333)
• Co-Investigator(Kenkyū-buntansha): YAMANE Akira 鶴見大学, 歯学部, 教授 (20166763)
• Project Period (FY): 2010 – 2012
• Keywords: 歯科補綴学一般

Research Abstract

The present study attempt to elucidate the function of miRNAs in the atrophy of tongue and masticatory muscles with aging and to explore the treatment. The miRNA play significant roles in the development of tongue and masticatory muscles and might provide the muscle atrophy with very useful treatment for the muscle atrophy.

Research Products

• [Journal Article] Role of occlusion in mouse masseter muscleacetylcholine receptor clustering. (2013)
  • Author(s): MORI, M., NARIYAMA, M., ABO, T., HIRAI, S., OGAWA, T., HAMADA, Y., YAMANE, A. and ASADA, Y.
  • Journal Title: J. Dent. Res. Volume: 92(4) Pages: 352-357
  • Peer Reviewed
• [Journal Article] Association between the lack of teeth and the expression of myosins in masticatory muscles of microphthalmic mouse. (2012)
  • Author(s): NARIYAMA, M., KOTA, Y., KANEKO, S., ASADA, Y. and YAMANE, A.
  • Journal Title: Cell Biochem. Func. Volume: 30(1) Pages: 82-88
  • Peer Reviewed
• [Journal Article] The function of platelet derived growth factor in the differentiation of mouse tongue striated muscle. (2012)
  • Author(s): SUZUKI, E., AOYAMA, K., FUKUI, T., NAKAMURA, Y. and YAMANE, A.
  • Journal Title: Orthod. Craniofac. Volume: Res.15(1) Pages: 39-51
  • Peer Reviewed
• [Journal Article] IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a b2-adrenergic agonist. (2012)
  • Author(s): ABO, T., IIDA, R., KANEKO, S., SUGA, T.,YAMADA, H., HAMADA, Y. and YAMANE, A.
  • Journal Title: CellBiochem. Func. Volume: 30(8) Pages: 671-676
  • Peer Reviewed
• [Journal Article] Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging. (2011)
  • Author(s): IIDA, R., KANEKO, S., SUGA, T., MORITO, M. and YAMANE, A.
  • Journal Title: Mol. Cell. Biochem. Volume: 348(1) Pages: 89-98
  • Peer Reviewed
• [Journal Article] Bone morphogenetic protein-2 functions as a negative regulator, but not as an inducer for the formations of cartilage and bone in cultured tongue, in the differentiation of myoblasts in mouse embryonic tongue. (2011)
  • Author(s): AOYAMA, K., YAMANE, A., SUGA, T., SUZUKI, E., FUKUI, T. and NAKAMURA, Y.
  • Journal Title: BMC Dev. Volume: Biol. Pages: 11-44
  • Peer Reviewed
• [Journal Article] Changes in triacylglycerol-accumulated fiber type, fiber type composition, biogenesis in the mitochondria of the soleus muscle in obese rats. (2011)
  • Author(s): KANEKO, S., IIDA, R., SUGA, T., FUKUI, T., MORITO, M. and YAMANE, A.
  • Journal Title: Anat. Volume: Rec.294(11) Pages: 1904-1912
  • Peer Reviewed
• [Journal Article] Changes in the expression of myosins during postnatal development of masseter muscle in the microphthalmic mouse. (2010)
  • Author(s): KATAYMA, R., YAMANE, A. and FUKUI, T.
  • Journal Title: Open Dent. Volume: J. 4:1-7
  • Peer Reviewed
• [Journal Article] TGFb3 is expressed in differentiating muscle of the embryonic mouse tongue. (2010)
  • Author(s): YAMANE, A. FUKUI, T., SUGA, T., IIDA, R. and MORITO, M.
  • Journal Title: Int. J. Dev. Volume: Biol.54(1) Pages: 221-226
  • Peer Reviewed
• [Journal Article] BMP-2 regulates the formation of oral sulcus in mouse tongue by altering the balance between TIMP-1 and MMP-13. (2010)
  • Author(s): FUKUI, T., SUGA, T., IIDA, R., MORITO, M., LUAN, X., DIEKWISCH, T.G.H., NAKAMURA, Y. and YAMANE, A.
  • Journal Title: Anat. Volume: Rec. 293(8) Pages: 1408-1415
  • Peer Reviewed
• [Journal Article] Effect of the classic 1 week glycogen-loading regimen on the fat-loading in the rat and human. (2010)
  • Author(s): SHINOHARA, A., TAKAKURA, J., YAMANE, A. and SUZUKI, M.
  • Journal Title: J. Nutr. Sci. Volume: Vitaminol.56(5) Pages: 299-304
  • Peer Reviewed
• [Journal Article] Effect of third molar absence on development of masticatory muscles in EL mice. (2010)
  • Author(s): NARIYAMA, M., KOTA, Y., TASHIMA, I., TOMOHIRO, T., YAMANE, A. andASADA, Y.
  • Journal Title: Pediatric Dent. J. Volume: 20(2) Pages: 122-129
  • Peer Reviewed
• [Journal Article] Changes in the lingual muscles of obese rats induced by high-fat diet. (2010)
  • Author(s): SAITO, T., YAMANE, A., KANEKO, S., OGAWA, T., IKAWA, T., SAITO, K. and SUGISAKI, M.
  • Journal Title: Arch. Oral Biol. Volume: 55(10) Pages: 803-808
  • Peer Reviewed
• [Journal Article] Age-related changes in rat genioglossus, geniohyoid, and masseter muscles.
  • Author(s): KANEKO, S., IIDA, R., SUGA, T., MORITO, M. and YAMANE, A.
  • Journal Title: Gerodontology Volume: (In press)
  • Peer Reviewed