2012 Fiscal Year Final Research Report
Development of a novel bone induction method for dental implant based on the mechanism of fracture healing
| Project/Area Number |
22592172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Tokyo Dental College (2011-2012)
Matsumoto Dental University (2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRAGA Toru 松本歯科大学, 歯学部, 准教授 (70322170)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 顎口腔機能学 |
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| Research Abstract |
In this study, we focused on fracture-induced osteoblast precursor cells (FOPC), which are the cells accumulated at sites of fracture and committed to the osteoblast lineage, and attempted to establish a new bone induction method using a rat fracture model. Immunohistochemical examination showed the accumulation and proliferation of bone marrow-derived Thy-1 (CD90)-positive osteogenic cells, suggesting their possible involvement in fracture healing.
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