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2012 Fiscal Year Final Research Report

Development of a novel bone induction method for dental implant based on the mechanism of fracture healing

Research Project

  • PDF
Project/Area Number 22592172
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthetic dentistry
Research InstitutionTokyo Dental College (2011-2012)
Matsumoto Dental University (2010)

Principal Investigator

YAMASHITA Shuichiro  東京歯科大学, 歯学部, 教授 (80242212)

Co-Investigator(Kenkyū-buntansha) HIRAGA Toru  松本歯科大学, 歯学部, 准教授 (70322170)
Project Period (FY) 2010 – 2012
Keywords顎口腔機能学
Research Abstract

In this study, we focused on fracture-induced osteoblast precursor cells (FOPC), which are the cells accumulated at sites of fracture and committed to the osteoblast lineage, and attempted to establish a new bone induction method using a rat fracture model. Immunohistochemical examination showed the accumulation and proliferation of bone marrow-derived Thy-1 (CD90)-positive osteogenic cells, suggesting their possible involvement in fracture healing.

  • Research Products

    (11 results)

All 2013 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results)

  • [Journal Article] Thy-1-positive cells in the subodontoblastic layer possess high potential to differentiate into hard tissue-forming cells2012

    • Author(s)
      Hosoya A、Hiraga T、Ninomiya T、Yukita A、Yoshiba K、Yoshiba N、Takahashi M、Ito S、Nakamura H
    • Journal Title

      Histochemistry and Cell Biology

      Volume: 137 Pages: 733-742

    • DOI

      DOI:10.1007/s00418-012-0928-1

    • Peer Reviewed
  • [Journal Article] Location of main occluding areas and masticatory ability in patients with implant-supported prostheses2012

    • Author(s)
      Tanigawa Y、Kasahara T、Yamashita S
    • Journal Title

      Australian Dental Journal

      Volume: 57 Pages: 171-177

    • Peer Reviewed
  • [Journal Article] Localization of Thy-1-positive cells in the perichondrium during endochondral ossification2010

    • Author(s)
      Nakamura H、 Yukita A、 Ninomiya T、 Hosoya A、Hiraga T、Ozawa H
    • Journal Title

      Journal of Histochemistry & Cytochemistry

      Volume: 58 Pages: 455-462

    • Peer Reviewed
  • [Journal Article] 下顎臼歯部における咬合の再建にインプラントを用いた1症例2010

    • Author(s)
      山下秀一郎
    • Journal Title

      日本口腔インプラント学会誌

      Volume: 23 Pages: 757-758

    • URL

      http://ci.nii.ac.jp/naid/10027841839

    • Peer Reviewed
  • [Presentation] Location of main occluding areas in patients with implant -supported prostheses2013

    • Author(s)
      Tanigawa Y、Yamashita S、Mitsui T、Kasahara T
    • Organizer
      91th General Session of the IADR
    • Place of Presentation
      Washington State Convention & Trade Center、Seattle、USA
    • Year and Date
      2013-03-23
  • [Presentation] インプラント療法を希望した患者の臨床調査 -過去2年間の調査結果の比較2012

    • Author(s)
      西田 茜、松崎文頼、古屋克典、関根秀志、山下秀一郎
    • Organizer
      第42回日本口腔インプラント学会学術大会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2012-09-22
  • [Presentation] 臼歯部咬合支持の喪失をインプラントと部分床義歯で補綴処置した場合の主機能部位の比較2011

    • Author(s)
      谷川雄一、笠原隼男、 山下秀一郎、鷹股哲也
    • Organizer
      第41回日本口腔インプラント学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-09-17
  • [Presentation] Thy-1 陽性 subodontoblastic layer 細胞の高い硬組織形成能2011

    • Author(s)
      細矢明宏、 平賀 徹、二宮 禎、雪田 聡、吉羽邦彦、吉羽永子、中村浩彰
    • Organizer
      第9回日本再生歯科医学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2011-09-10
  • [Presentation] Comparison of main occluding areas between implant and denture patients、International Association for Dental Research2011

    • Author(s)
      Tanigawa Y、Nakatsuka Y、Yamashita S、Kasahara T、 Hashii K
    • Organizer
      89th General Session of the IADR
    • Place of Presentation
      San Diego Convention Center、San Diego、USA
    • Year and Date
      2011-03-17
  • [Presentation] Thy-1 陽性歯髄細胞の硬組織形成能に関する形態学的研究2010

    • Author(s)
      細矢明宏、 平賀 徹、二宮 禎、雪田 聡、吉羽邦彦、吉羽永子、中村浩彰
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2010-09-20
  • [Presentation] 安全で確実なインプラント治療に必要となる解剖学的知識2010

    • Author(s)
      井出吉信、山下秀一郎(座長)
    • Organizer
      第40回日本口腔インプラント学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2010-09-18

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Published: 2014-08-29  

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