2012 Fiscal Year Final Research Report
Modulation of angiogensis in bone regeneration
| Project/Area Number |
22592197
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
SATO Shuichi 日本大学, 歯学部, 講師 (50225942)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 血管新生 / 骨 / 再生 |
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| Research Abstract |
This study evaluated angiogenesis in rat non-critical and critical calvarial flat bone defects using in vivo micro-CT. Critical- and non-critical-sized calvarial bone defects showed bone regeneration and angiogenesis around the midsagittal suture. New blood vessel networks were observed around defects of both sizes. Angiogenesis preceded bone regeneration around critical- and non-critical-sized calvarialbone defects. Angiogenesis led to full bone formation in non-critical-sized defects
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