2012 Fiscal Year Final Research Report
The elucidation of a mechanotransduction mechanism to the joint destruction in the temporomandibular joint synovial cell
| Project/Area Number |
22592204
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDA Masayuki 秋田大学, 医学部, 准教授 (20272049)
NAGAI Hirokazu 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (50282190)
NAKATA Akira 秋田大学, 医学部, 助教 (50400510)
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| Project Period (FY) |
2010 – 2012
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| Keywords | メカニカルストレス / 顎関節 / メカノトランスダクション / 培養滑膜細胞 / 破骨細胞 / 関節破壊 |
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| Research Abstract |
In this study, the mechanical stress considered to participate in development of symptoms and advance of temporomandibular disorder was added to the human temporomandibular joint synovial cells, and the elucidation of the mechanotransduction mechanism in a synovial cell. Since the cultured cell became extinct under the influence of the Great East Japan Earthquake, although it did not result in the elucidation of sufficient signal transfer, promotion of formation and the mechanism of the osteoclast by compression stimulus of the synovial cells were clarified.
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