2012 Fiscal Year Final Research Report
The analysis of histone modification in 4NQO-induced rat tongue cancer model
| Project/Area Number |
22592211
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAKITA Hiroki 岐阜大学, 大学院・医学系研究科, 講師 (50345790)
KATO Keizo 岐阜大学, 医学部附属病院, 講師 (40397336)
SHIBATA Toshiyuki 岐阜大学, 大学院・医学系研究科, 教授 (50226172)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 口腔癌 |
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| Research Abstract |
We aim to examine the usefulness of 4-NQO induced rat tongue cancer as human oral carcinogenesis model .In order to verify whether changes in the overall level of H3K4,H3K9 histone methylation,the level of H3K4me3,H3K9me2,me3 were measured in 4-NQO induced rat tongue cancer model by western blotting.Our results suggest that the level of H3K9me2 was increased in squamous cell carcinoma of rat at 32 weeks from beginning of administration.Therefore, 4-NQO induced rat tongue cancer model is suggested the usefulness as human oral carcinogenesis model .
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