2012 Fiscal Year Final Research Report
Analysis of the early aberrant DNA methylation and influence of demethylation agent in the 4NQO-induced rat tongue cancer model
| Project/Area Number |
22592212
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Gifu University |
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Principal Investigator |
KATO Keizo 岐阜大学, 医学部附属病院, 講師 (40397336)
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| Co-Investigator(Kenkyū-buntansha) |
HARA Akira 岐阜大学, 大学院・医学系研究科, 教授 (10242728)
SHIBATA Shibata 岐阜大学, 大学院・医学系研究科, 教授 (50226172)
MAKITA Hiroki 岐阜大学, 大学院・医学系研究科, 講師 (50345790)
YAMASHITA Tomomi 岐阜大学, 大学院・医学系研究科, 准教授 (80345793)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 癌 メチル化 |
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| Research Abstract |
Epigenetic alteration attracts attention of the carcinogenesis process. However, it is difficult to examine at early time without the lesion. Therefore we examined in4NQO-induced rat tongue carcinogenesis model. The gene examined p16 and MGMT .In addition, we examined epigallocatechin gallate (EGCG) about demethylating ability .As a result, the significant change of the methylation status did not occur in each period. However, slightly controlled tendency was seen in the protein level in EGCGgroup. By these results, the carcinogenesis agent does not bring the epigenetic alteration, immediately . It was shown that long-term sustained influence participated.Furthermore, the possibility was shown that EGCG was effective by the long-term dosage.
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[Journal Article] Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.2012
Author(s)
Kudo Y, Iizuka S, Yoshida M, Nguyen PT, Siriwardena SB, Tsunematsu T, Ohbayashi M, Ando T, Hatakeyama D, Shibata T, KoizumiK, Maeda M, Ishimaru N, Ogawa I, Takata T.
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Journal Title
Peer Reviewed
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