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2012 Fiscal Year Final Research Report

Ionic channel mechanisms in oscillatory cellular bursting underlying respiratory rhythm

Research Project

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Project/Area Number 22592214
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

YAMANISHI Tadashi  大阪大学, 歯学研究科(研究院), 招へい教員 (20397780)

Co-Investigator(Kenkyū-buntansha) MIYA Shigenori  大阪大学, 歯学研究科(研究院), 助教 (00397762)
TANIGUCHI Yoshitaka  大阪大学, 歯学研究科(研究院), 招へい教員 (10551468)
IHSIBASHI Miki  大阪大学, 歯学研究科(研究院), 招へい教員 (40412051)
Project Period (FY) 2010 – 2012
Keywords口腔外科学一般
Research Abstract

The brainstem pre-Botzinger complex (pre-BotC), the essential excitatory circuit for respiratory rhythm generation, contains a subset of neurons that exhibit intrinsic rhythmic bursting. The burst initiation is considered to rely on the persistent Na+current (INaP), but cellular mechanisms that regulate burst frequency and duration are unknown. Using whole-cell patch-clamp, computational modeling, and dynamic-clamp, we provide evidence that INaP regulates all the essential features of rhythmic burst generation. The results show how the kinetic properties of INaPorchestrate neuronal oscillatory bursting.

  • Research Products

    (4 results)

All 2012 2011 2010

All Journal Article (2 results) Presentation (2 results)

  • [Journal Article] Role of endothelin receptor signalling in squamous cell carcinoma2012

    • Author(s)
      Ishimoto S, Wada K, Tanaka N, Yamanishi T, et al
    • Journal Title

      International Journal of Oncology

      Volume: 40 Pages: 1011-1019

  • [Journal Article] Early two-stage double opposing Z-plasty or one-stage push-back palatoplasty?: comparisons in maxillary development and speech outcome at 4 years of age2011

    • Author(s)
      Yamanishi T, Nishio J, et al
    • Journal Title

      Annals of Plastic Surgery

      Volume: 66 Pages: 148-153

  • [Presentation] Working Heart Brainstem Preparation を用いた嚥下活動の解析2012

    • Author(s)
      青海哲也、山西 整、原田 丈史ら
    • Organizer
      第57回日本口腔外科学会総会・学術大会
    • Place of Presentation
      パシフィコ横浜会議センター、弘前大学
    • Year and Date
      2012-10-20
  • [Presentation] 不確縫線核ニューロンによる呼吸恒常性の維持機構2010

    • Author(s)
      山西 整、原田 丈史ら
    • Organizer
      第55回日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張メッセ、東京歯科大学
    • Year and Date
      2010-10-17

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Published: 2014-08-29  

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