2012 Fiscal Year Final Research Report

Ionic channel mechanisms in oscillatory cellular bursting underlying respiratory rhythm

Research Project

Project/Area Number	22592214
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	Osaka University
Principal Investigator	YAMANISHI Tadashi 大阪大学, 歯学研究科(研究院), 招へい教員 (20397780)
Co-Investigator(Kenkyū-buntansha)	MIYA Shigenori 大阪大学, 歯学研究科(研究院), 助教 (00397762) TANIGUCHI Yoshitaka 大阪大学, 歯学研究科(研究院), 招へい教員 (10551468) IHSIBASHI Miki 大阪大学, 歯学研究科(研究院), 招へい教員 (40412051)
Project Period (FY)	2010 – 2012
Keywords	口腔外科学一般
Research Abstract	The brainstem pre-Botzinger complex (pre-BotC), the essential excitatory circuit for respiratory rhythm generation, contains a subset of neurons that exhibit intrinsic rhythmic bursting. The burst initiation is considered to rely on the persistent Na+current (INaP), but cellular mechanisms that regulate burst frequency and duration are unknown. Using whole-cell patch-clamp, computational modeling, and dynamic-clamp, we provide evidence that INaP regulates all the essential features of rhythmic burst generation. The results show how the kinetic properties of INaPorchestrate neuronal oscillatory bursting.

(4 results)