2012 Fiscal Year Final Research Report
Study of steroid-induced and bisphosphonate-induced osteonecrosis
| Project/Area Number |
22592219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAJIOKA Shunichi 九州大学, 医学研究院, 特任准教授 (90274472)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ビスフォスフォネート / ステロイド / スタチン / 顎骨壊死 |
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| Research Abstract |
To investigate the pharmacological effects of steroid and bisphosphonate on bone, we tried to establish proliferative epithelial cells and fat-derived mesenchymal stem cells. In this study, we established epithelial cells and CD105-positive mesenchymal stem cells which can differentiate into osteoblasts. Next, we investigated the effects of statin on osteoclastogenesis in RAW 264.7 cells. In this study, it was suggested that atorvastatin and simvastatin may stimulate osteoclastogenesis indirectly by inducing the RANK expression via increasing the expression of TNF-α through MAPK pathways in RAW 264.7 cells.
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