2012 Fiscal Year Final Research Report
Study of the defense mechanism against infection of dental epithelial cell
| Project/Area Number |
22592225
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Norifumi 鹿児島大学, 医学部・歯学部附属病院, 教授 (60217875)
KOMATSUZAWA Hitoshi 鹿児島大学, 医歯学総合研究科, 教授 (90253088)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 歯原性上皮細胞 / 抗菌ペプチド / 口腔外科 / 感染 / 細胞増殖 |
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| Research Abstract |
Radicular cyst is one of the periapical lesion, their formation is associated with the proliferation of epithelial cell rests of Malassez. However, little is currently known about the precise mechanisms of formation and enlargement of radicular cysts. The purpose of this study is to examine the levels of antimicrobial activities of periapical lesions, therefore, we evaluate the levels of antimicrobial peptide (AMP) and E-cadherin in periapical lesion and dental epithelial cell lines. These observations suggest that dental epithelial cells can secrete AMPs and consolidate epithelial intercellular junctions when stimulated by bacterial infection,and radicular cysts may play an important role in defense mechanisms.
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