2012 Fiscal Year Final Research Report
Original approach to obtain intrinsic resistance genes to cisplatin
| Project/Area Number |
22592237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHIRO Yoichi 北海道大学, 大学院・歯学研究科, 講師 (40301915)
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| Co-Investigator(Kenkyū-buntansha) |
TOTSUKA Yasunori 北海道大学, 名誉教授 (00109456)
KITAMURA Tetsuya 北海道大学, 大学院・歯学研究科, 助教 (00451451)
SHINDOH Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 抗癌剤耐性 |
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| Research Abstract |
This study investigated the relationship between cisplatin resistance and osteopontin which is candidate gene responsible for drug resistance. Oral squamous cell carcinoma cells transfected with osteopontin were increased in resistance to cisplatin treatment and in activity of AKT. Knockdown of osteopontin chemosensitized cancer cells to cisplatin. The resistance mechanism of osteopontin was depend on AKT activation. These results suggest that osteopontin expression in oral cancer could be a useful predictable marker for the response to cisplatin.
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