Notch signaling as a therapeutic target in oral squamous cell carcinoma

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592241
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kagoshima University
• Principal Investigator: HIJIOKA Hiroshi 鹿児島大学, 大学院・医歯学総合研究科, 助教 (70305150)
• Co-Investigator(Kenkyū-buntansha): SETOGUCHI Takao 鹿児島大学, 医歯学総合研究科, その他 (40423727) ; MIYAWAKI Akihiko 産業医科大学, 附属病院, 講師 (40200216) ; ISHIDA Takayuki 鹿児島大学, 医歯学総合研究科, 助教 (20404501) ; KOMIYA Setsuro 鹿児島大学, 医歯学総合研究科, 教授 (30178371) ; NAKAMURA Norifumi 鹿児島大学, 医歯学総合研究科, 教授 (60217875)
• Project Period (FY): 2010 – 2012
• Keywords: Notchシグナル / 口腔扁平上皮癌 / EMT / 低酸素

Research Abstract

The aim of this study is to investigate the significance of Notch signaling in oral squamous cell carcinoma(OSCC) and to explore the potential of new molecular target therapy for OSCC. We demonstrated that Notch signaling is activated in OSCC and inhibition of Notch pathway prevents OSCC growth. Further we showed hypoxia induced EMT in OSCC via activation of Notch signaling. These findings suggest that inhibition of Notch pathway may be a useful approach for the treatment of patients with OSCC.

Research Products

• [Journal Article] The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cells (2013)
  • Author(s): Kume K, Haraguchi M, Hijioka H, Ishida T, Miyawaki A, Nakamura N, Ozawa M
  • Journal Title: Biochemical and Biophysical Research Communications18 Volume: 430 Pages: 889-894
  • URL: http://dx.doi.org/10.1016/j.bbrc.2012.12.060
  • Peer Reviewed
• [Journal Article] A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis (2013)
  • Author(s): Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, Miyawaki A, Semba I, Nakamura N, Kiyono T, Kishida S
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 115(6) Pages: 780-8
  • DOI: DOI:10.1016/j.oooo.2013.03.005
  • Peer Reviewed
• [Journal Article] Analysis of the outcome of concurrent neoadjuvant chemo radiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell caricinoma (2012)
  • Author(s): Miyawaki A., Hijioka H., Ikeda R., Ishida T., Nozoe E.,NakamuraN.
  • Journal Title: Oncol.Letter Volume: 3 Pages: 995-1001
  • DOI: DOI:10.3892/ol.2012.606
  • Peer Reviewed
• [Journal Article] Upregulation of Notch pathway molecules in oral squamous cell carcinoma (2010)
  • Author(s): Hijioka H, Setoguchi T, Miyawaki A, Gao H, Ishida T, Komiya S, and Nakamura N
  • Journal Title: Int J Oncol Volume: 36 Pages: 817-822
  • DOI: DOI:10.3892/ijo_00000558
  • Peer Reviewed
• [Journal Article] Relationship between SUV of PET and Hypoxic environment of Oral squamous cell caricinoma (2010)
  • Author(s): Miyawaki A., Ikeda R., Hijioka H., Ishida T., Nakamura N
  • Journal Title: Oncology Report Volume: 23 Pages: 1205-1212
  • DOI: DOI:10.3892/or_00000751
  • Peer Reviewed
• [Journal Article] Smoothened as a new therapeutic target for human osteosarcoma (2010)
  • Author(s): Hirotsu M., Setoguchi T., Sasaki H. Matsunoshita Y., Gao H., Nagao H., Kunigou O., Komiya S
  • Journal Title: Molecular Cancer Volume: 9 Pages: 5
  • Peer Reviewed
• [Presentation] 当科における口腔扁平上皮癌症例に対する取り組みと治療成績 (2013)
  • Author(s): 比地岡浩志, 石田喬之, 久米健一, 吉村卓也, 西原一秀, 野添悦郎, 中村典史
  • Organizer: 第31回日本口腔腫瘍学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-01-24
• [Presentation] Notch signaling induced EMT in oral squamous cell carcinoma under hypoxic environment (2012)
  • Author(s): Hijioka H, Ishida T, Kume K, Yoshimura T, Miyawaki A, Nakamura N
  • Organizer: 10th Asian Congress on Oral and Maxillofacial Surgery
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2012-11-16
• [Presentation] 口腔扁平上皮癌において転写因子 Snail は E-cadherin と desmoglein 2の分解を亢進する (2012)
  • Author(s): 久米健一, 原口みさ子, 比地岡浩志, 宮脇昭彦, 石田喬之, 中村典史, 小澤政之
  • Organizer: 第85回日本生化学学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-05-17
• [Presentation] 低酸素環境下での口腔扁平上皮癌細胞の上皮間葉移行における Notch シグナルの意義 (2011)
  • Author(s): 石田喬之、比地岡浩志、宮脇昭彦、岐部俊郎、久米健一、中村典史
  • Organizer: 第56回日本口腔外科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2011-10-21
• [Presentation] The role of Wnt signaling pathway in growth characteristics of Ameloblastoma cells (2011)
  • Author(s): Kibe T, Kishida S, Hijio ka H, Miyawaki A, Nakamura N
  • Organizer: 11th Annual Meeting of Indonesian Association of Oral and Maxillofacial Surgery
  • Place of Presentation: Batam, Indonesia
  • Year and Date: 2011-09-21