2012 Fiscal Year Final Research Report
Development of cancer peptide vaccine therapy for oral cancer
| Project/Area Number |
22592242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Akira 札幌医科大学, 医学部, 講師 (10210353)
KOBAYASHI Jyunichi 札幌医科大学, 医学部, 助教 (80404739)
YAMAMOTO Takashi 札幌医科大学, 医学部, 研究員 (50448594)
道振 義貴 札幌医科大学, 医学部, 研究員 (00457722)
佐々木 敬則 札幌医科大学, 医学部, 研究員 (50548732)
藤野 準己 札幌医科大学, 医学部, 研究員 (60620945)
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| Project Period (FY) |
2010 – 2012
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| Keywords | がんペプチドワクチン / がん抗原 / 口腔がん / サバイビン / がん免疫 |
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| Research Abstract |
We have confirmed the safety and efficacy of a cancer peptide vaccine therapy using a survivin2B-derived peptide decomposed from a survivin protein that is highly expressed in many malignancies. Furthermore, a clinical trial indicated that when using the peptide in conjunction with stimulants, a stronger immune effect could be obtained than from the peptide alone. The trial also confirmed the safety of the vaccine therapy. In the quest to develop a cancer peptide vaccine other than survivin, we have identified molecules that are highly expressed in cancer stem cells of the oral cavity, and established a foundation towards a more effective clinical application of cancer peptide vaccine therapy.
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[Journal Article] 進行・再発口腔がんに対するサバイビン2B ペプチドワクチン療法の第I 相臨床試験2012
Author(s)
小林淳一,宮崎晃亘,山本崇,道振義貴,佐々木敬則,山口 晃,仲盛健治,荻 和弘,永井 格,鳥越俊彦,廣橋良彦,佐藤昇志,平塚博義.
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Journal Title
北海道頭頸部腫瘍研究会々誌
Volume: 37
Pages: 8-11
Peer Reviewed
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[Journal Article] High expression of ALDH1 and SOX2 diffusestaining pattern of oral squamous cell carcinomas correlates to lymph node metastasis2012
Author(s)
MichifuriY,HirohashiY,TorigoeT,MiyazakiA,KobayashiJ,Sasaki T,FujinoJ,Asanuma H,Tamura Y,Nakamori K,Hasegawa T,Hiratsuka H,Sato N
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Journal Title
Pathol Int
Volume: 62
Pages: 684-689
DOI
Peer Reviewed
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[Journal Article] Phase I clinical trial of survivinderived peptide vaccine therapy for patients with advanced or recurrent oral cancer2011
Author(s)
Miyazaki A,Kobayashi J,Torigoe T,Hirohashi Y,Yamamoto T,Yamaguchi A,Asanuma H,Takahashi A,Michifuri Y,Nakamori K,Nagai I,Sato N,Hiratsuka H
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Journal Title
Cancer Sci
Volume: 102
Pages: 324-329
DOI
Peer Reviewed
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