Thermochemotherapy with controlled drug delivery using a novel magnetic anti-cancer drug

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592243
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University
• Principal Investigator: MITSUDO Kenji 横浜市立大学, 医学部, 准教授 (70303641)
• Co-Investigator(Kenkyū-buntansha): TOHNAI Iwai 横浜市立大学, 医学研究科, 教授 (50172127) ; KUROTANI Reiko 横浜市立大学, 医学研究科, 特任助教 (00453043)
• Project Period (FY): 2010 – 2012
• Keywords: 口腔癌 / 新規磁性抗癌剤 / 家兎 VX2 癌 / 温熱療法 / Drug Delivery System

Research Abstract

A new magnetic anticancer drug (=New drug) was developed giving an anti-tumor effect by fragmenting DNA and controlling cell proliferation, depending on its density. The New drug is characterized by being a magnetic substance, which accumulates locally through impression of a magnetic field using a permanent magnet. As a result, it could be used as a drug delivery system. In addition, it was clarified that the New drug generates heat because of the high frequency magnetic field impression; thus, it is expected to be effective for intra-tissue hyperthermia.We performed a comparative MTT assay assessing the antitumor effects of the New drug against cisplatin(CDDP), an anticancer drug mainly used for oral cancer. We also created a tongue tumor model into which the VX2 cell line was transplanted, and performed an animal experiment using the New drug. This result suggests that EI236 become a new drug for the treatment of oral cancer.

Research Products

• [Journal Article] Thermochemoradiotherapy for Oral Cancer with N2, 3 Cervical Lymph Node Metastases using Retrograde Superselective Intra-Arterial Infusion (2012)
  • Author(s): Mitsudo K, Koizumi T, Iida M, Mitsunaga S, Tohnai I
  • Journal Title: Themal Med Volume: 28(2) Pages: 23-28
  • Peer Reviewed
• [Journal Article] Thermochemoradiotherapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases. (2012)
  • Author(s): Mitsudo K, Koizumi T, Iida M, Iwai T, Oguri S, Yamamoto N, Itoh Y, Kioi M, Hirota M, Tohnai I.
  • Journal Title: Inl J Radiat Oncol Biol Phys Volume: 83(5) Pages: e639-e645
  • Peer Reviewed
• [Presentation] Development of oral cancer treatment using a new magnetic anticancer drug (2012)
  • Author(s): Sato I, Mitsudo K, Iida M, Nakashima H, Eguchi H, Koizumi T, Kioi M, Ishikawa Y, Tohnai I
  • Organizer: 11th International Congress of Hyperthermic Oncology
  • Place of Presentation: Hyatt Kyoto
  • Year and Date: 2012-08-31
• [Presentation] Clinical evaluation of thermochemoradiotherapy for advancedhead and neck cancer. (2012)
  • Author(s): Iida M, Mitsudo K, Koizumi T, Iwai T, Oguri S, Kioi M, Hirota M, Nakashima H, Tohnai I
  • Organizer: 11th International Congress of Hyperthermic Oncology
  • Place of Presentation: Hyatt Kyoto
  • Year and Date: 2012-08-30
• [Presentation] Thermochemoradiotherapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for advanced oral cancer with cervical lymph node metastases. (2012)
  • Author(s): Koizumi T, Mitsudo K, Iida M, Iwai T, Oguri S, Kioi M, Hirota M, Tohnai I
  • Organizer: 11th International Congress of Hyperthermic Oncology
  • Place of Presentation: Hyatt Kyoto
  • Year and Date: 2012-08-30
• [Presentation] Hyperthermia sensitizes resistant human oral cancer cells to IL-13 cytotoxin (2012)
  • Author(s): Nakashima H, Kioi M, Ookubo M, Sugiura K, Sato I, Iida M, Mitsudo K, Husain SR, Puri RK, Tohnai I
  • Organizer: 11th International Congress of Hyperthermic Oncology
  • Place of Presentation: Hyatt Kyoto
  • Year and Date: 2012-08-30
• [Presentation] Thermochemoradiotherapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases (2012)
  • Author(s): Mitsudo K, Koizumi T, Iida M, Iwai T, Oguri S, Yamamoto N, Kioi M, Hirota M, Tohnai I.
  • Organizer: 11th International Congress of Hyperthermic Oncology
  • Place of Presentation: Hyatt Kyoto
  • Year and Date: 2012-08-30
• [Presentation] Hyperthermia using magnetic nanoparticle combined with intratumoral dendritic cells enhance antitumor effect. (2012)
  • Author(s): Yamamoto N, Matsumoto K, Furue H, Hagiwara S, Nishikawa M, Hibi H, Shigetomi T, Mitsudo K, Tohnai I, Kobayashi T, Ueda M.
  • Organizer: 11th International Congress of Hyperthermic Oncology
  • Place of Presentation: Hyatt Kyoto
  • Year and Date: 2012-08-30
• [Presentation] Organ preservation with daily concurrent chemoradiotherapy using retrograde superselective intra-arterial infusion for stage III, IV oral cancer: analysis of therapeutic results in 112 Cases (2012)
  • Author(s): Mitsudo K, Koizumi T, Iwai T, Nakashima H, Oguri S, Kioi M, Hirota M, Tohnai I
  • Organizer: American Society of Clinical Oncology (ASCO) Annual Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2012-06-01
• [Presentation] Thermochemoradiotherapy using superselective intra-arterial infusion via a superficial temporal artery and an occipital artery for N3 cervical lymph node metastases of oral cancer. (2011)
  • Author(s): Mitsudo K, Yamamoto N, Koizumi T, Iwai T, Nishiguchi H, Hirota M, Tohnai I
  • Organizer: 3rdWorld Congress of International Academy of Oral Oncology
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2011-07-15