functional analysis of novel two specific oral cancer marker detected from saliva

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592245
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Showa University
• Principal Investigator: MATSUURA Mitsuhiro 昭和大学, 歯学部, 助教 (00297037)
• Co-Investigator(Kenkyū-buntansha): SHINTANI Satoru 昭和大学, 歯学部, 教授 (80294429)
• Project Period (FY): 2010 – 2012
• Keywords: 唾液

Research Abstract

Salivary proteomic analysis was performed to obtein a reliable screening test for early diagnosis of oral squamous cell carcinoma and that the cystatin SN and salivary acidic proline-rich phosphoprotein 3/4 might be a promising tumor biomarker for oral squamous cell carcinoma.

Research Products

• [Journal Article] A potential anticancer activity of extracts derived from the roots of Scutellaria baicalensis on humanoral squamous cell carcinoma cells (2013)
  • Author(s): Sato D, Yazawa K, Kondo S, Mukudai Y, Li C,Kamatani T, Katsuta H, Yoshihama Y,Shirota T,Shintani S
  • Journal Title: Molecular and Clinical Oncology Volume: 1 Pages: 105-111
  • DOI: DOI:10.3892/mco.2012.14
  • Peer Reviewed
• [Journal Article] The root bark of Paeonia moutan is a potential anticancer agent in human oral squamous cell carcinoma cells (2012)
  • Author(s): Li C, Yazawa K, Kondo S, Mukudai Y, Sato D,Kurihara Y, Kamatani T, Shintani S
  • Journal Title: Anticancer research Volume: 32 Pages: 2625-2630
  • Peer Reviewed
• [Journal Article] Friend leukaemia insertion (Fli)-1 is a prediction marker candidate for radiotherapy resistant oral leukaemia insertion (Fli)-1 is a predictionmarker candidate for radiotherapy resistant oral squamous cell carcinoma (2010)
  • Author(s): Shintani S, Hamakawa K, Nakashiro K, Shirota T, Hatori M, Tanaka,M, Kuroshita Y, Kurokawa Y
  • Journal Title: International Journal of Oral Maxillofacial Surgery Volume: 39(11) Pages: 1115-1119
  • Peer Reviewed
• [Journal Article] Identification of a truncated cystatin SA-1 as a saliva biomarker for oral squamous cell carcinoma using the SELDI ProteinChip platform (2010)
  • Author(s): Shintani S, Hamakawa H, Ueyama Y, Hatori M, Toyoshima T
  • Journal Title: International Journal of Oral Maxillofacial Surgery Volume: 39(1) Pages: 439-443
  • Peer Reviewed
• [Journal Article] Genome-wide cDNA microarray screening to reveal gene-expression profiles correlated to chemosensitivity of oral squamous cell carcinoma cell lines (2010)
  • Author(s): Shintani S, Nakashiro K, Hamakawa H, Shirota T, Hatori M, Kawamoto Y, Sasaki A
  • Journal Title: Asian Journal of Oral Maxillofacial Surgery Volume: 22 Pages: 7-11
  • Peer Reviewed
• [Presentation] Epigenomic profiling of oral cancer (2012)
  • Author(s): Yoshiba S, Nagae G, Kaneda A, Tsuji S, Matsusaka K, Yagi, K, Isagawa T, Tachikawa T, Shintani S, Aburatani H
  • Organizer: 2012AACR
  • Place of Presentation: chicago, Illinois, USA
  • Year and Date: 2012-04-05
• [Presentation] Telomerase-Specific Replication-Selective Virotherapy combined with radiation therapy for oral squamous cell carcinoma cells (2012)
  • Author(s): Kurihara Y, Sato D, Shirota T, Kondo S, Kataoka M, Urata Y, Fujiwara T, Shintani S
  • Organizer: 2012AACR
  • Place of Presentation: chicago, Illinois, USA
  • Year and Date: 2012-04-05
• [Presentation] Telomerase-Specific Replication-Selective oncolytic viruses for adenoid cystic. carcinoma cell lines (2012)
  • Author(s): Sato D, Kurihara Y, Kondo S, ShirotaT,Urata Y, Fujiwara T, Shintani S
  • Organizer: 2012AACR
  • Place of Presentation: chicago, Illinois, USA
  • Year and Date: 2012-04-05
• [Presentation] Saliva tumor markers for the identification of oral cancer European (2008)
  • Author(s): Shintani S, Hatori,M Toyoshima T, Kurihara Y, Kurokawa Y, Nakahira H, Ito T, Shirota T
  • Organizer: Association for Cranio-Maxillofacial Surgery
  • Place of Presentation: Bologna Italy
  • Year and Date: 20081109-12
• [Remarks]
  • URL: http://www.omfs-showa.jp/