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2012 Fiscal Year Final Research Report

A study on interaction of cancer stem cells and microenvironment (niche)and stromal fibroblasts (CAF)

Research Project

  • PDF
Project/Area Number 22592248
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionHyogo Medical University

Principal Investigator

MORIDERA Kuniyasu  兵庫医科大学, 医学部, 助教 (60461076)

Co-Investigator(Kenkyū-buntansha) NOGUCHI Kazuma  兵庫医科大学, 医学部, 講師 (50309473)
URADE Masahiro  兵庫医科大学, 医学部, 教授 (70104883)
Project Period (FY) 2010 – 2012
Keywords臨床腫瘍学
Research Abstract

We divided SP cells with cell line of SCC-25,OSC-19,OSC-20.We confirmed SP cells with one of three extraction specimens which obtained its consent from the patients. The CD44-positive surgery specimen had much 4D of the YK classification.We were able to confirm that there was the specimen which couldn't divide SP cells even if CD44 was positive, and only CD44 did not become the marker of stem cells. The speed of the cell proliferation is slow, and there is not passage with all cell line though it cultures discrete SP cells in a serum-free medium.The cells did not perish for approximately around one month, but it developed that a growth rate wasslow than person normal cells.

  • Research Products

    (19 results)

All 2013 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (14 results)

  • [Journal Article] HPV陽性および陰性の口腔扁平上皮がんに対するinvitro多段階発がんモデル2013

    • Author(s)
      頭司雄介、野口一馬、浦出雅裕
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 59(3) Pages: 159-171

    • Peer Reviewed
  • [Journal Article] An in vitro multistep carcinogenesis model for bothHPV-positive and-negative humanOral squamous cell carcinoma.2011

    • Author(s)
      Yusuke Zushi, Mako Narisawa-Saito,Kazuma Noguchi, Yuki Yoshimatsu, Takashi Yugawa, Nagayasu Egawa, Masatoshi Fujita, Masahiro Urade, Tohru Kiyono
    • Journal Title

      Am J Cancer Res

      Volume: 1(7) Pages: 869-881

    • URL

      www.ajcr.us/ISSN:2156-6976/ajcr0000079

    • Peer Reviewed
  • [Journal Article] Up-regulation of neutrophil gelatinase-associated lipocalin in oral squamous cell carcinoma:Relation to celldifferentiation2011

    • Author(s)
      Takashi Hiromoto, Kazuma Noguchi,Michiyo Yamamura, Yusuke Zushi,Emi Segawa, Kazuki Takaoka, Kuniyasu Moridera, Hiromitsu Kishimoto, Masahiro Urade
    • Journal Title

      Oncol Rep

      Volume: 26 Pages: 1415-1421

    • DOI

      DOI:10.3892/or.2011.1429

    • Peer Reviewed
  • [Journal Article] Promotion of hematogeneous metastatic potentials in human KBcarcinoma cells with overexpressionof cyclooxygenase-2.2010

    • Author(s)
      Emi Segawa, Hiromitsu Kishimoto,Kazuki Takaoka, Kazuma Noguchi, Susumu Hashitani, Kazunari Sakurai, Masahiro Urade
    • Journal Title

      Oncol Rep

      Volume: 24 Pages: 733-739

    • DOI

      DOI:10.3892/or.2011.1429

    • Peer Reviewed
  • [Journal Article] Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2.2010

    • Author(s)
      Nao Ohtsu, Kazuki Takaoka, Emi Segawa,Susumu Hashitani, Kazuma Noguchi, Hiromitsu Kishimoto, Masahiro Urade
    • Journal Title

      Oncol Rep

      Volume: 24 Pages: 31-36

    • DOI

      DOI:10.3892/or_00000825

    • Peer Reviewed
  • [Presentation] 口腔発がんにおけるp53,EGFR,Ras遺伝子発現の関連性について?不死化ヒト正常舌ケラチノサイト(HTK)を用いた解析?2012

    • Author(s)
      頭司雄介、野口一馬、吉川恭平、岸本裕充、浦出雅裕
    • Organizer
      第66回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2012-05-17
  • [Presentation] 口腔扁平上皮癌培養細胞を用いたシスプラチン耐性における銅排出輸送体ATP7Bの発現とその関与の検討2011

    • Author(s)
      吉川恭平、野口一馬、山村倫世、頭司雄介、高岡一樹、岸本裕充、浦出雅裕
    • Organizer
      第48回日本口腔組織培養学会学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
  • [Presentation] 不死化ヒト正常ケラチノサイト(HTK)を用いた口腔癌のHPV陽性、陰性モデル解析2011

    • Author(s)
      頭司雄介、野口一馬、山村倫代、高岡一樹、瀬川英美、岸本裕充、浦出雅裕
    • Organizer
      第48回日本口腔組織培養学会学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
  • [Presentation] Effect of NOS inhibitors and CXCR4 antagonist on tumor growth and metastasis of human adenoid cystic carcinoma xenografted into nude mice.2011

    • Author(s)
      Kazuki Takaoka, Sayaka Hidaka, SusumuHashitani, Yusuke Zushi, Michiyo Yamamura, Emi Segawa, Kazuma Noguchi, Hiromitsu Kishimoto, Masahiro Urade
    • Organizer
      20th International Conference on Oraland Maxillofacial Surgery
    • Place of Presentation
      SantiagoChile
    • Year and Date
      2011-11-02
  • [Presentation] An in vitro multistep carcinogenesis Model for both HPV positive and-negative human oral squamous cell carcinoma.2011

    • Author(s)
      Yusuke Zushi, Kazuma Noguchi, MichiyoYamamura, Kazuki Takaoka, Kuniyasu Moridera, Emi Segawa, Shin Okui, Hiromitsu Kishimoto, Masahiro Urade
    • Organizer
      20th International Conference on Oraland Maxillofacial Surgery
    • Place of Presentation
      Santiago, Chile
    • Year and Date
      2011-11-02
  • [Presentation] 不死化ヒト正常舌ケラチノサイト(HTK)を用いた口腔癌のHPV陽性、陰性モデルの解析2011

    • Author(s)
      頭司雄介、野口一馬、山村倫世、高岡一樹、森寺邦康、瀬川英美、奥井森、岸本裕充、浦出雅裕
    • Organizer
      第56回(社)日本口腔外科学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-21
  • [Presentation] 口腔扁平上皮癌細胞の上皮・間葉移行(EMT)におけるzyxinの関与2011

    • Author(s)
      瀬川英美、野口一馬、高岡一樹、頭司雄介、岸本裕充、浦出雅裕
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
  • [Presentation] A functional analysisof zxin in epithelial-mesenchymal transition of oral squamous cell carcinoma.2011

    • Author(s)
      Michiyo Yamamura, Kazuma Noguchi,Emi Segawa, Yusuke Zushi, KazukiTakaoka, Hiromitsu Kishimoto, Masahiro Urade
    • Organizer
      16th European Cancer Congress
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2011-09-25
  • [Presentation] Masahiro Urade:Up-regulation of neutrophil gelatinase-associated lipocalin in oral squamous cell carcinoma: Relation to cell differentiation.2011

    • Author(s)
      Kazuma Noguchi, Takashi Hiromoto,Michiyo Yamamura, Yusuke Zushi,Emi Segawa, Kazuki Takaoka, Kuniyasu Moridera, Hiromitsu Kishimoto
    • Organizer
      16th European Cancer Congress
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2011-09-25
  • [Presentation] 口腔癌細胞におけるZyxinの発現および機能の検討2010

    • Author(s)
      山村倫世、野口一馬、瀬川英美、高岡一樹、頭司雄介、廣本孝史、岸本裕充、浦出雅裕
    • Organizer
      第47回日本口腔組織培養学会学術大会
    • Place of Presentation
      高知
    • Year and Date
      2010-11-13
  • [Presentation] 口腔扁平上皮癌におけるNGALの発現2010

    • Author(s)
      廣本孝史、野口一馬、山村倫世、瀬川英美、頭司雄介、岸本裕充、浦出雅裕
    • Organizer
      第47回日本口腔組織培養学会学術大会
    • Place of Presentation
      高知
    • Year and Date
      2010-11-13
  • [Presentation] 口腔癌細胞におけるEMTmarkerとしてのzyxinの発現2010

    • Author(s)
      瀬川英美、野口一馬、山村倫世、高岡一樹、頭司雄介、岸本裕充、橋谷進、浦出雅裕
    • Organizer
      第55回(社)日本口腔外科学会学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-10-16
  • [Presentation] 舌扁平上皮癌の形成・分化度におけるNeutrophilgelatinase-associatedLipocalin(NGAL)の発現2010

    • Author(s)
      廣本孝史、野口一馬、瀬川英美、頭司雄介、山村倫世、岸本裕充、浦出雅裕
    • Organizer
      第64回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-25
  • [Presentation] 高転移能を有するマウス未分化癌に対するCXCR4拮抗剤とNOS阻害剤の腫瘍増殖および転移抑制効果2010

    • Author(s)
      日高紗弥香、橋谷進、頭司雄介、田中徳昭、高岡一樹、浦出雅裕
    • Organizer
      第64回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-25

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Published: 2014-08-29  

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