2012 Fiscal Year Final Research Report
Modulatory influence of ovariectomy on orofacial neuropathic pain in rats
| Project/Area Number |
22592256
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NIWA Hitoshi 大阪大学, 大学院・歯学研究科, 教授 (30218250)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 卵巣摘出 / 更年期 / 神経障害性疼痛 / 三叉神経 / 女性ホルモン / 口腔顔面痛 / エストロゲン / 漢方 |
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| Research Abstract |
We studied the effects of goshajinkigan (GJG) on mechanical hypersensitivity in ovariectomized rats with infraorbital nerve injury using the von Frey test. The results showed the potential development of gradual analgesic action with chronic administration of GJG. In addition, a difference was apparent between the ovariectomy and sham operation groups, and thus ovariectomy itself may reduce the analgesic effect induced by GJG. Examination of the effects of estradiol (Es) replacement in the same model indicated that Es acted to aggravate acute inflammation while mitigating chronic conditions such as neuropathic pain.
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