Localization of Perlecan and Heparanase in the Epithelial

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592269
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: SUGAHARA Toshio 愛知学院大学, 歯学部, 客員教授 (10116048)
• Co-Investigator(Kenkyū-buntansha): HIRATA Azumi 大阪医科大学, 医学部, 助教 (40263587) ; MINAMI Katsuhiro 愛知学院大学, 歯学部, 講師 (70346162) ; FUJIWARA Kumiko 愛知学院大学, 歯学部, 講師 (60404737) ; IMURA Hideto 愛知学院大学, 歯学部, 非常勤講師 (10513187)
• Project Period (FY): 2010 – 2012
• Keywords: 口蓋裂 / 発生メカニズム / パールカン / 上皮索基底膜 / 口蓋突起

Research Abstract

We examined the immunolocalization pattern of heparan sulfate (HS) and heparanase (HPSE) in order to clarify their roles in murine palatal boneformation in palatogenesis.Heparanase might contribute to the formation of hard palate bycleaving of heparan sulfate chains of HSPG in bone matrix.

Research Products

• [Journal Article] Effect of 2,3,7,8-tetrachlorodibenzo-p- dioxin suggests abnormal palate development after palatal fusion (2010)
  • Author(s): Imura H, Yamada T, Mishima K, Fujiwara K, Kawaki H, Hirata A, Sogawa N, Ueno T, Sugahara T
  • Journal Title: Congenit Anom Volume: 50(2) Pages: 77-84
  • Peer Reviewed
• [Journal Article] Localization of the HOXChomeobox gene family during palateformation in mice (2010)
  • Author(s): Hirata, A., Tsuji, T., Imura, H., Yamada,T., Ueno, T., Mishima, K., Natsume, N.,Sugahara, T., Koga, Y., Takano, K. andNakamura, H.
  • Journal Title: Selected papersfrom the XX Congress of the European Association of Cranio-Maxillo-FacialSurgery Pages: 415-420
  • Peer Reviewed
• [Presentation] Total TMJ replacement for obstructive sleep apnea syndrome associated with TMJ destruction due to rheumatoid arthritis (2012)
  • Author(s): Toshio SUGAHARA, Katsuhiro MINAMI, Katsuaki MISHIMA, Yoshihide MORI,Tomohiro YAMADA, Hideto IMURA, Azumi HIRATA, Nagato NATSUME
  • Organizer: XXI Congress of the European Assosiation of Cranio-Maxillo-Facial Surgery (Dubrovnik) Croatia
  • Year and Date: 20120911-15
• [Presentation] HEPARANASELOCALIZATION DURING PALATOGENESIS INMICE (2012)
  • Author(s): Azumi Hirata, Hideto Imura, TakaakiUeno, Katsuhiro Minami, NagatoNatsume, Toshio Sugahara
  • Organizer: XXI Congress of the EuropeanAssosiation of Cranio-Maxillo-FacialSurgery(Dubrovnik)Croatia
  • Year and Date: 20120911-15
• [Presentation] Homeobox familyHOX遺伝子は口蓋形成に関与する (2011)
  • Author(s): 平田あずみ、井村英人、南克浩、夏目長門、菅原利夫
  • Organizer: 第56回日本口腔外科学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-10-21
• [Presentation] Localization of HeparanSulfate and Heparanase during PalatalBone Formation in Palatogenesis in Mice (2010)
  • Author(s): Tosho Sugahara
  • Organizer: EUROPEAN ASSOCIATION FOR C
  • Place of Presentation: RANIO-MAXILLO-FACIAL SURGER2010 Congress Bruges
  • Year and Date: 20100914-17
• [Book] 口腔外科専門医マニュアル (2011)
  • Author(s): 菅原利夫
  • Total Pages: 72-105
  • Publisher: 医歯薬出版