A genome-wide association study for maxilla-facial deformity using pooled DNA typing

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592272
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Fukuoka Dental College (2012); Hokkaido University (2010-2011)
• Principal Investigator: KAJII Takashi 福岡歯科大学, 准教授 (60322822)
• Project Period (FY): 2010 – 2012
• Keywords: 歯科矯正学 / 基礎ゲノム科学

Research Abstract

At first, we conducted second screening of a genome-wideassociation study of mandibular prognathism. Over 10 of microsatellite markers showedsignificant association with mandibular prognathism from the result of second screening.Next we conducted individual typing (third screening) of a genome-wide association studyof mandibular prognathism. It was suggested that 1p22.3, 1q32.2, and 15q22.2 are candidateloci for mandibular prognathism.

Research Products

• [Journal Article] Congenital and postnatal factors inducing malocclusions in Japanese unilateral cleft lip and palate patients- determination using logistic regression analysis. (2013)
  • Author(s): Kajii TS, Alam MK, Mikoya T, Oyama A,Koshikawa-Matsuno M, Sugawara-Kato Y, Sato Y, Iida J
  • Journal Title: Cleft Palate-Craniofacial Journal Volume: 50
  • Peer Reviewed
• [Journal Article] 成長期の骨格性下顎前突症における下顎骨の過大な成長の予測-形態学的研究とゲノム解析を用いて-. (2012)
  • Author(s): 梶井貴史
  • Journal Title: 福岡歯科大学学会雑誌 Volume: 38巻 Pages: 139-144
• [Journal Article] Histological study of the nasal septal cartilage in BALB/c-bm/bm mouse which spontaneously induces malocclusion. (2012)
  • Author(s): Takahashi K, Kajii TS, Tsukamoto Y, Saito F, Wada S, Sugawara-Kato Y, Iida J
  • Journal Title: Orthodontics and Craniofacial Research Volume: 15 Pages: 84-91
  • Peer Reviewed
• [Journal Article] Morphological evaluation of cranial and maxillary shape differences of the brachymorphic mouse with spontaneous malocclusion using three-dimensional micro-computed tomography. (2011)
  • Author(s): Saito F, Kajii TS, Sugawara-Kato Y,Tsukamoto Y, Arai Y, Hirabayashi Y,Fujimori O, Iida J
  • Journal Title: Orthodontics and Craniofacial Research Volume: 14 Pages: 100-106
  • Peer Reviewed
• [Journal Article] Three-dimensional cranio-maxillary characteristics of the mouse with spontaneous malocclusion using micro-computed tomography. (2011)
  • Author(s): Saito F, Kajii TS, Sugawara-Kato Y,Tsukamoto Y, Arai Y, Hirabayashi Y,Fujimori O, Iida J
  • Journal Title: European Journal of Orthodontics Volume: 33 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Relationship between degree of malocclusion and occlusal interference in mice that spontaneously develop anterior transverse crossbite. (2010)
  • Author(s): Tsukamoto Y, Kajii TS, Sugawara-Kato Y,Hirabayashi Y, Fujimori O, Iida J
  • Journal Title: American Journal of Orthodontics and Dentofacial Orthopedics Volume: 138 Pages: 710.e1-710.e5
  • Peer Reviewed
• [Presentation] 下顎前突症(mandibular prognathism)のゲノムワイド関連解析 (2012)
  • Author(s): 生野啓一郎、梶井貴史、岡晃、斉藤文男、猪子英俊、石川博之、飯田順一郎
  • Organizer: 日本人類遺伝学会第57回大会
  • Place of Presentation: 東京
  • Year and Date: 20120000
• [Presentation] Congenital and postnatal factors affecting malocclusions of Japanese unilateral cleft lip and palate patients Using multivariate statistical analysis-. (2011)
  • Author(s): Kajii TS, Sato Y, Iida J
  • Organizer: The meeting of the 20th anniversary celebration of sister school affiliation between Graduate School of Dental Medicine
  • Place of Presentation: Hokkaido University and School of Dentistry,Chonbuk National University, Jeju
  • Year and Date: 20110000
• [Presentation] 顎変形症の発症原因解明に対する考察-顎変形症自然発症モデル動物を用いて- (2010)
  • Author(s): 梶井貴史、飯田順一郎
  • Organizer: 第20回日本顎変形症学会総会
  • Year and Date: 20100000