The examination of the expression of chemokines and RANKL in root resorption during orthodontic tooth movement

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592297
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Nihon University
• Principal Investigator: YAMAGUCHI Masaru 日本大学, 松戸歯学部, 准教授 (60333100)
• Project Period (FY): 2010 – 2012
• Keywords: 歯科矯正 / 歯根吸収 / ケモカイン / RANKL

Research Abstract

The immunoreactivity for CINC-1/CXCR2 , MCP-1 and RANKL were detected in odontoclasts and PDL fibroblasts by the orthodontic force of 50 g on day 7. CF increased the production of IL-8, MCP-1 and RANKL from hPDL cells in a magnitude-dependent manner. Moreover, CINC-1,MCP-1 and RANKL stimulated osteoclastogenesis from rat osteoclast precursor cells.Conclusion: IL-8 (CINC-1), MCP-1 and RANKL may facilitate the process of root resorptiondue to excessive orthodontic force.

Research Products

• [Journal Article] Morphological and Histological Changes in the Mandibular Condyle after Plate Removal in Experimental Models of Short- and Long-term Mandibular Lateral Displacement. (2013)
  • Author(s): Ando J, Yamaguchi M, Fujita S, KawamuraA, Utsunomiya T, Kasai K.
  • Journal Title: J Hard Tissue Biol Volume: 22 Pages: 201-210
• [Journal Article] Effect of compression force on apoptosis in human periodontal ligament cells. (2013)
  • Author(s): Funakoshi M, Yamaguchi M, Asano M,Kasai K.
  • Journal Title: J Hard Tissue Biol Volume: 22 Pages: 41-50
• [Journal Article] Immunohistochemical localization of T-helper 17 cells, IL-17, and RANKL during root resorption induced by excessive orthodontic force in a mouse model of T cell-mediated autoimmune disease. (2012)
  • Author(s): Yamaguchi M, Yamada M, Asano M, Fujita S, Kasai K.
  • Journal Title: Int J Oral-Med Sci Volume: 11 Pages: 249-260
• [Journal Article] Localization of TNF-α andmacrophages in the periodontalligament during orthodontic tooth movement. (2012)
  • Author(s): Funakoshi M, Yamaguchi M, Fujita S,Kasai K.
  • Journal Title: Int J Oral-Med Sci Volume: 11 Pages: 182-181
• [Journal Article] Orthodontic root resorption was associated with the secretion of IL-6 and IL-8 stimulated by IL-17 in dental pulp cells. (2012)
  • Author(s): Shimizu M, Yamaguchi M, Asano M, FujitaS, Utsunomiya T, Yamamoto H, Kasai K.
  • Journal Title: Int J Oral-Med Sci Volume: 11 Pages: 172-189
• [Journal Article] T-helper 17 cells mediate the osteo/odontoclastogenesis induced by excessive orthodontic forces. (2012)
  • Author(s): Hayashi N, Yamaguchi M, Nakajima R,Utsunomiya T, Yamamoto H, Kasai K.
  • Journal Title: Oral Dis Volume: 18(4) Pages: 375-388
• [Journal Article] IL-8 and MCP-1 induced by excessive orthodontic force mediates odontoclastogenesis in periodontal tissues. (2011)
  • Author(s): Asano M, Yamaguchi M, Nakajima R,Fujita S, Utsunomiya T, Yamamoto H, Kasai K.
  • Journal Title: Oral Dis Volume: 17(5) Pages: 489-498
• [Journal Article] Expressions of RANKL/RANK and M-CSF/c-fms in root resorption by excessive orthodontic force. (2011)
  • Author(s): Nakano Y, Yamaguchi M, Fujita S, AsanoM, Saito K, Kasai K.
  • Journal Title: Eur J Orthod. Volume: 33(4) Pages: 335-343
• [Journal Article] IL-17/Th17 cells in an atopic dermatitis mouse model aggravate orthodontic root resorption in dental pulp.
  • Author(s): Shimizu M, Yamaguchi M, Utsunomiya M, Yamamoto H, Kasai K.
  • Journal Title: Eur J Oral Sci Volume: 121(2) Pages: 101-10
  • DOI: doi:10.1111/eos.12024.
• [Journal Article] Th17-cells in atopic dermatitis stimulate orthodontic root resorption.
  • Author(s): Yamada K, Yamaguchi M, Asano M, FujitaS, Kobayashi R, Kasai K.
  • Journal Title: Oral Dis
  • DOI: doi:10.1111/odi.12053.
• [Presentation] ヒト歯髄組織中のIL-17が炎症性サイトカイン産生および歯根吸収に及ぼす影響. (2012)
  • Author(s): 清水真美,山口大,浅野正貴,葛西一貴.
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡.
  • Year and Date: 2012-09-27
• [Presentation] アレルギーは矯正学的歯の移動時に生じる歯根吸収を増悪する. (2012)
  • Author(s): 山田邦彦,山口大,小林良喜,浅野正貴,安藤淳,宇都宮忠彦,山本正文,山本浩嗣,葛西一貴.
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2012-09-27
• [Presentation] メカニカルストレスがヒト歯根膜線維芽細胞の細胞死に与える影響. (2012)
  • Author(s): 船越麻理,山口大,小林良喜,浅野正貴,葛西一貴.
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2012-09-27
• [Presentation] TNF-αが矯正学的歯の移動時に生じる歯根吸収に及ぼす影響. (2012)
  • Author(s): 吉野智一,山口大,菊田純,葛西一貴.
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡.
  • Year and Date: 2012-09-27
• [Presentation] 次世代歯科矯正学の研究シーズ戦略-歯根吸収発現予測診断と後戻り抑制薬-. (2012)
  • Author(s): 山口大.
  • Organizer: BIOtech2012第11回バイオテクノロジー展/技術会議
  • Place of Presentation: 東京
  • Year and Date: 2012-04-25
• [Presentation] K.HSP70 inhibits the compressionforce-induced TNF-α and RANKL expression. (2011)
  • Author(s): Yamaguchi M, Mituhashi M, kasai
  • Organizer: 10th World of congress on inflammation
  • Place of Presentation: paris, France
  • Year and Date: 20110625-29
• [Presentation] Effects of IL-17 on the expression ofRANKL from human dental pulp cells. (2011)
  • Author(s): Shimizu M, Yamaguchi M, kasai K.
  • Organizer: 10th World of congress on inflammation
  • Place of Presentation: paris, France
  • Year and Date: 20110625-29
• [Presentation] IL-8/RANKL increasedIL-8/RANKL increased by excessive orthodonticforce in periodontal ligament induces orthodontically-induced inflammatory root resorption. (2011)
  • Author(s): Funakoshi M, Yamaguchi M, Asano M,nakojima R, Fujita S, kasai K.
  • Organizer: 10th World of congress on inflammation
  • Place of Presentation: paris, France
  • Year and Date: 20110625-29
• [Presentation] The participation of interleukin 17 and RANKL in root resorption of the allergic mouce. (2011)
  • Author(s): Yamada K, Yamaguchi M, Fujita S, AsanoM, Ando J, Utsunomiya T, Yamamoto H, kasai K.
  • Organizer: 10th World of congress on inflammation
  • Place of Presentation: paris, France
  • Year and Date: 20110625-29
• [Presentation] IL-17stimulates IL-6 productionand osteoclastogenesis in human periodontal ligament cells. (2011)
  • Author(s): Hayashi N, Yamaguchi M, kasai K.
  • Organizer: 10th World of congress on inflammation
  • Place of Presentation: paris, France
  • Year and Date: 20110625-29
• [Book] In Principles in Contemporary Orthodontics. (2011)
  • Author(s): Yamaguchi M,他
  • Total Pages: 43-52