2013 Fiscal Year Final Research Report
Analysis of Genome Methylation Profile in Relation to Common Mechanisms of Periodontitis and Rhematoid Arthritis Onset
| Project/Area Number |
22592309
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOMATSU Yasutaka 新潟大学, 医歯学総合病院, 助教 (40422597)
|
|---|
| Project Period (FY) |
2010-04-01 – 2014-03-31
|
| Keywords | 歯周炎 / リウマチ / インターロイキン６ / ゲノム / メチル化 |
|---|
| Research Abstract |
The aim of the present study is to elucidate the role of methylation status of interleukin-6 (IL-6) gene in regulation of signal expression in relation to susceptibility to periodontitis and rheumatoid arthritis (RA), because of the similarities in the pathologic features of these diseases. The results indicated that patients with periodontitis and RA showed the hypomethylated status of IL-6 gene and increased IL-6 levels than healthy control individuals. These results suggest that IL-6 gene methylation may play a role in the pathogenesis of periodontitis and RA.
|
-
[Journal Article] Amino acid profiles in relation to chronic periodontitis and rheumatoid arthritis2014
Author(s)
Kobayashi T, Okada M, Ito S, Kobayashi D, Shinhara A, Muramatsu T, Kobayashi T, Narita I, Nakazono K, Murasawa A, Yoshie H
-
Journal Title
Open Journal of Stomatology
Volume: 4(2)
Pages: 49-55
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
