How periodontitis can affect prostate cancer metastasis?

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592312
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Okayama University
• Principal Investigator: TANIMOTO Ichiro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00280686)
• Co-Investigator(Kenkyū-buntansha): WATANABE Masami 岡山大学, 岡山大学病院, 准教授 (70444677) ; NARUISHI Koji 岩手医科大学, 歯学部, 歯学部 (00346446) ; MINESHIBA Junji 岡山大学, 岡山大学, 講師 (00509383) ; OMORI Kazuhiro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20549860) ; TAKASHIBA Syogo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50226768)
• Project Period (FY): 2010 – 2012
• Keywords: 歯周炎 / 慢性炎症 / 癌転移

Research Abstract

In the present study, we demonstrated the opposite association between localized and systemic inflammatory responses. Our finding suggests that appropriate infectious exposure might be needed to maintain our life. Taken together, a severe sepsis-like condition elicited by bacteremia, is likely responsible for the mortality associated with P. gingivalisinfection, but immune system would regulate the unwanted systemic responses. These systemic responses may alsoimpact metastatic cancer.

Research Products

• [Journal Article] Secreted caveolin-1 enhances periodontal inflammation by targeting gingival fibroblasts (2013)
  • Author(s): Takizawa N, Sawada S, Chosa N, Ishisaki A, Naruishi K
  • Journal Title: Biomed Res Volume: 34(1) Pages: 1-11
• [Journal Article] Naruishi K, Omori K, Maeda H, Sonoi N, Funakoshi K, Hirai K, Ishii M, Kubo K, Kobayashi H, Tomiyama T, Yamamoto D, Tanimoto I,Kunimatsu K, and Takashiba S (2011)
  • Author(s): Naruishi K, Omori K, Maeda H, Sonoi N, Funakoshi K, Hirai K, Ishii M, Kubo K, Kobayashi H, Tomiyama T, Yamamoto D, Tanimoto I,Kunimatsu K, and Takashiba S
  • Journal Title: J Biol Regul Homeost Agents Volume: 25(2) Pages: 195-202