2012 Fiscal Year Final Research Report
A study on the mechanisms involved in the invasion of host cells by periodontal pathogens and the novel method for its regulation
| Project/Area Number |
22592317
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
SAITO Atsushi 東京歯科大学, 歯学部, 教授 (60266559)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Kazuyuki 東京歯科大学, 歯学部, 教授 (00212910)
INAGAKI Satoru 東京歯科大学, 歯学部, 助教 (20385165)
KOKUBU Eitoyo 東京歯科大学, 歯学部, 助教 (70453785)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 歯周炎 / 歯周病原細菌 / 侵入 / バイオフィルム |
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| Research Abstract |
In order to gain insight into the mechanism and significance of host cell invasion by periodontal bacteria in polymicrobial infecti on, we assessedPorphyromonas gingivalis invasion of gingival epithelial cells enhanced by Fusobacterium nucleatum. Confocal scanning laser microscopy and antibiotic protection assay were used to study the role of P. gingivalis invasin (SerB) in this phenomena. The results from the experiment using SerB-mutant strain showed that the P. gingivalis invasin does not play a major role in this phenomenon. It was demonstrated that lipid raft was involved in fusobacterial enhancement of P. gingivalis invasion.
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[Journal Article] 細菌における免疫回避機構の解明2013
Author(s)
齋藤 淳,加藤哲男,菊池有一郎,国分栄仁,今村健太郎
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Journal Title
平成 24 年度東京歯科大学口腔科学研究センターワークショップ, 平成 25 年 3月 1 日,千葉市美浜区. 平成 24 年度東京歯科大学口腔科学研究センターワークショップ プログラムおよび抄録集
Pages: 41
Peer Reviewed
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