Mechanism of transcriptional regulation of extracellular matrix and transcription factors which control periodontal regeneration.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592319
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Nihon University
• Principal Investigator: OGATA Yorimasa 日本大学, 歯学部, 教授 (90204065)
• Co-Investigator(Kenkyū-buntansha): TAKAI Hideki 日本大学, 歯学部, 助教 (30453898)
• Project Period (FY): 2010 – 2012
• Keywords: 転写調節 / 転写因子 / 骨芽細胞 / 石灰化 / 細胞外マトリックス / 歯周組織再生

Research Abstract

Protamine induced BSP transcription by targeting CRE, FRE and HOX sites in the proximal promoter of the rat BSP gene. Moreover, phospho-CREB, c-Fos, c-Jun, JunD, Fra2, Dlx5, Msx2, Runx2 and Smadl transcription factors appear to be key regulators of protamine effects on BSP transcription.

Research Products

• [Journal Article] Transcriptional regulation of human bone sialoprotein gene by fibroblast growth factor 2. (2013)
  • Author(s): Zhou L, Ogata Y.
  • Journal Title: J Oral Science Volume: 55 Pages: 63-70
  • Peer Reviewed
• [Journal Article] Protamine stimulates bone sialoprotein gene expression. (2013)
  • Author(s): Zhou L, Matsumura H, Mezawa M, Takai H, Nakayama Y, Mitarai M, Ogata Y.
  • Journal Title: Gene Volume: 516 Pages: 228-237
  • DOI: Doi:10.1016/j.gene.2012.12.056.
  • Peer Reviewed
• [Journal Article] Aggregatibacter actinomycetemcomitans lipopolysaccharide regulates bone sialoprotein gene transcription. (2012)
  • Author(s): Li X, Zhou L, Takai H, Sasaki Y, Mezawa M, Li Z, Wang Z, Yang L, Wang S, Matsumura H, Kaneko T, Yoshimura A, Ogata Y.
  • Journal Title: J Cell Biochem Volume: 113 Pages: 2822-2834
  • DOI: Doi:10.1002/jcb.24157
  • Peer Reviewed
• [Journal Article] Fibroblast growth factor 2 and forskolin induce mineralization-associated genes in two kinds of osteoblast-like cells. (2012)
  • Author(s): Nakayama Y, Yang L, Takai H, Kaneko H, Abiko Y, Ogata Y.
  • Journal Title: J Oral Sci Volume: 54 Pages: 251-259
  • Peer Reviewed
• [Presentation] Mitotic transcription factor circuits control the molecular phenotype of mesenchymal cells. (2012)
  • Author(s): Takai H, van Wijnen AJ, Ogata Y.
  • Organizer: JADR meeting
  • Place of Presentation: Niigata
  • Year and Date: 20121214-15
• [Presentation] single nucleotide polymorphism rs11536889 in 3'-untranslated region of TLR4 contributes to the regulation of Toll-like receptor 4 expression. (2012)
  • Author(s): Yoshimura A, Sato K, TKaneko T, Li X, H. Matsumura H, Ogata Y, Hara Y. A
  • Organizer: International Endotoxin and Innate Immunity Society (IEIIS) meeting
  • Place of Presentation: Tokyo
  • Year and Date: 20121023-26
• [Presentation] Transcriptional Regulation of Bone Sialoprotein Gene by Aggregatibacter actinomycetemcomitans Lipopolysaccharide. (2012)
  • Author(s): Ogata Y, Takai H, Zhou L, Matsumura H, Li X.
  • Organizer: IADR meeting
  • Place of Presentation: Brazil
  • Year and Date: 20120620-23
• [Presentation] Effects of Protamine on Bone Sialoprotein Gene Expression. (2012)
  • Author(s): Zhou L, Matsumura H, Sasaki Y, Mezawa M, Ogata Y.
  • Organizer: IADR meeting
  • Place of Presentation: Brazil
  • Year and Date: 20120620-23
• [Presentation] Interleukin-11 Stimulates Bone Sialoprotein Gene Transcription. (2012)
  • Author(s): Matsumura H, Zhou L, Ogata Y.
  • Organizer: IADR meeting
  • Place of Presentation: Brazil
  • Year and Date: 20120620-23