2012 Fiscal Year Final Research Report
Categorization of the bacterial non-coding RNAs and development of the custom array
| Project/Area Number |
22592320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 歯周病 / 細菌 / non-coding RNA / マイクロアレイ |
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| Research Abstract |
For the purpose of development of the custom array for diagnoses to predict a risk of the periodontal disease, we paid attention the bacteria small non-coding RNAs as new targets of the diagnosis probes because they are associated with the bacterial pathogenic expressions and are hard to be disintegrated. Expressed RNAs in P. gingivalis were analyzed by a next - generation DNA sequencer cyclopedically. Several hundred kinds could be confirmed including predicted non-coding RNA in cilico. They are going to be utilizedas microarrays probe in future.
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